Recombinant Mouse Guanine nucleotide-binding protein G (q) subunit alpha (Gnaq)

1. Repeated treatment with methamphetamine (METH)increased behavioral sensitization as well as Galphaq/11 protein expression and Galpha protein activity in the striata of mice, while a single treatment of METH at the same dose did not affect these parameters. Repeated intrastriatal injections of a Galphaq/11 inhibitor reduced behavioral sensitization and striatal dopamine level in response to METH. PMID: 29223637
2. these data highlighted the critical role of Galphaq in regulating Th17 differentiation and multiple sclerosis pathogenesis PMID: 28216651
3. Emergence of a malignant phenotype may therefore arise from both under- and overexpression of Galpha11/q signaling, implicating its upstream regulation as a potential therapeutic target in a host of pathologic conditions PMID: 28301547
4. Galphaq regulates the development of rheumatoid arthritis by modulating Th1 differentiation PMID: 28197018
5. Fluid shear stress acts on the Galphaq-ERK5 signaling pathway to upregulate Cyclin B1 and CDK1 expression, thereby resulting in MC3T3-E1 cell proliferation. PMID: 27115838
6. cell-penetrating peptides should effectively inhibit active Galphaq in cells and that these and genetically encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor the spatiotemporal activation of Galphaq in cells. PMID: 27742837
7. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic. PMID: 27330078
8. The betaARKrgs peptide, but not endogenous GRK2, interacted with Galpha(q) and interfered with signaling through this G protein. These data support the development of GRK2-based therapeutic approaches to prevent hypertrophy and heart failure. PMID: 27016525
9. Galphaq/Galpha11 signaling pathways play a pivotal role in gene activity patterns during cardiac remodeling. PMID: 26476043
10. Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life. PMID: 26363170
11. demonstrate that the ability of an MC4R agonist delivered to PVN to inhibit food intake is lost in mice lacking G(q/11)alpha in the paraventricular nucleus of the hypothalamus but not in animals deficient for G(s)alpha PMID: 26595811
12. In studies with Gnaq(-/-) mice, Galphaq inhibited the differentiation of Th17 cell via regulating the activity of ERK-1/2 to control the expression of STAT3 and RORalpha. PMID: 25732870
13. results define specific modulation of spatial working memory and psychostimulant responses through disruptions in G(alphaq) signaling within cerebral cortical glutamatergic neurons PMID: 25963901
14. Gnaq was selectively inactivated in GnRH neurons of global Gna11--null mice. Galphaq/11-coupled signaling is a major conduit of GnRH secretion, results with these mice showed a role for non-Galphaq/11-coupled signaling in reproductive development and function. PMID: 26377475
15. Data show that the expression of the guanine nucleotide binding protein alpha q GNAQ(Q209L) allele induced causes the rapid development of uveal melanoma, with local invasion of blood vessels and multiple tumors developing in the lungs. PMID: 26113083
16. Fluorosed mouse ameloblasts have increased SATB1 retention and Galphaq activity. PMID: 25090413
17. Gq activation stimulated calcineurin activity, resulting in CN-dependent upregulation of TRPC6 in murine kidneys. PMID: 25844902
18. activation of ERK5 MAPK by model Gq-coupled GPCRs does not depend on receptor internalization, beta-arrestin recruitment or receptor phosphorylation but rather is dependent on Galphaq-signalling. PMID: 24358341
19. Precise temporal control of Gq signals in 5-HT2c-R domains in GABAergic neurons upstream of 5-HT neurons provides negative feedback regulation of serotonergic firing to modulate anxiety-like behavior in mice. PMID: 24733892
20. Lack of TRPC4 potentiation in neurons in the lateral nucleus of the amygdala affects two Galphaq/11 protein-coupled signaling pathways, implicated in fear-related behavior. PMID: 24599464
21. Galpha11 is essential for the development of cardiac hypertrophy in type I-diabetes. PMID: 22560942
22. This is the first conclusive evidence for the physiological importance of the activation of Gq/11 by the LH receptor and for the involvement of Galphaq/11 in ovulation. PMID: 23836924
23. Inhibition of Galphaq alters cell proliferation and is associated with decreased MMP-9 expression and activity PMID: 22595017
24. Suggest the involvement of the Gnaq and phosphatidylinositol 3-kinase signaling cascades in mediating melatonin effects in pancreatic alpha-cells. PMID: 22672634
25. Src family kinases, PI3 kinase and protein kinase C synergize to mediate Gq-dependent platelet activation PMID: 23066026
26. PKCzeta is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Galpha(q)/PKCzeta/ERK5 signaling axis. PMID: 22232556
27. Galpha(q) blockade abrogated the development of the heart failure phenotype in tetracycline-transactivating factor/V1A-transgenic mice. PMID: 21747049
28. rat monoclonal antibodies, specifically recognizing the deamidated Galpha(q), to detect the actions of Pasteurella multocida toxin deamidated Galpha(q) only under reducing conditions. PMID: 21624053
29. the Galpha(q) signal plays an inhibitory role in the PTH osteoanabolic action, suggesting that its suppression may lead to a novel treatment in combination with PTH against osteoporosis. PMID: 21345793
30. study describe the structure of PLC-beta3 in an activated complex with Galphaq, which together with supporting biochemical and physiological analyses reveals its mechanism of transmembrane signaling PMID: 20966218
31. Cellular G(i)-G(q) synergism derives from direct supra-additive stimulation of phospholipase C-beta3 by G protein subunits Gbetagamma and Galpha(q). PMID: 20579885
32. Gnaq expression by B cells is necessary for normal peripheral B cell development and tolerance induction and also plays a role in preventing early onset mortality in mice. PMID: 20624888
33. In Galphaq-induced cardiomyopathy, myocyte contractile dysfunction is mediated, at least in part, by 1 or more oxidative posttranslational modifications of SERCA. PMID: 20508180
34. Both PKCzeta and MEK5 associate to G alpha(q) upon activation of GPCR, thus forming a ternary complex that seems essential for the activation of ERK5. PMID: 20200162
35. In mouse pacreatic acini Galphaq links cholecystokinin stimulation to activation of Rac1, actin cytoskeletal reorganization and amylase secretion. PMID: 19940064
36. Ca(2+)-mediated inhibition of AC5/6 is an important mechanism of purinergic receptor-induced decline of cAMP in vascular smooth muscle cells. PMID: 19889965
37. MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq PMID: 11891332
38. Activation of Gq-coupled receptors on resident leukocytes in the lung elicits expression of GM-CSF, which in turn is required for allergen-induced pulmonary eosinophilia, identifying a novel pathway to pulmonary pathology in diseases such as asthma. PMID: 11907117
39. pathway is involved in orphan G protein-coupled receptors MrgA1 and MrgC11 which are activated by RF-amide-related peptides PMID: 12397184
40. The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets. PMID: 12604601
41. cholinergic receptor-mediated responses are dependent on Galphaq-mediated signaling events and Galphaq is a potential target of preventative/intervening therapies for lung dysfunction. PMID: 12611815
42. antisense to Galpha(q/11) significantly inhibited IL-6 production compared to control PMID: 12829380
43. an Akt-mediated cell survival pathway is compromised by the diminished availability of PIP2 elicited by pathological levels of Gq activity in cardiomyocytes PMID: 12900409
44. These data suggest that slow myosin heavy chain 2 repression in innervated fast pectoralis major fibers is mediated by cell signaling involving muscarinic acetylcholine receptors, G(alpha)q, and protein kinase C. PMID: 12952937
45. RGS proteins block Galpha(q)-mediated signal production by competing with downstream effectors for Galpha(q) binding. PMID: 14630933
46. We identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb. PMID: 15322542
47. PC1 signaling elevates intracellular Ca(2+), activates Galpha(q) and PLC, which then activates calcineurin and NFAT PMID: 15466861
48. prolonged activation of the Gq pathway desensitizes GnRH-induced signaling by selectively down-regulating the PLC-PKC-Ca2+ pathway, leading to reduced LHbeta synthesis and LH secretion PMID: 15878957
49. the inhibitory effect of Galpha q on the cardiac LTCC is mediated by inhibition of PI3K PMID: 16186103
50. activation of Galpha q in cardiac myocytes of adult mice causes a dilated cardiomyopathy that requires the activation of PLCbeta PMID: 16210321

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KEGG: mmu:14682

STRING: 10090.ENSMUSP00000025541

UniGene: Mm.439701