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  4. Recombinant Mouse Galanin peptides (Gal), partial

Recombinant Mouse Galanin peptides (Gal), partial

  • 货号：
    CSB-YP009191MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009191MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009191MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009191MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009191MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gal
  • Uniprot No.：
  • 别名：
    Gal; Galn; Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide; GMAP)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    33-61
  • 氨基酸序列
    GWTLNSAG YLLGPHAIDN HRSFSDKHGL T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
  • 基因功能参考文献：
    1. Galanin, acting via the GAL1 receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 and GIP secretion PMID: 26661062
    2. Galanin released by cancer induces neuritogenesis, facilitating perineural invasion. PMID: 25917569
    3. Study shows that LIF-treated postmitotic oligodendrocytes secrete a number of neuropeptides, in particular galanin, at the mRNA and peptide level, and galanin itself was shown to be a survival factor for oligodendrocytes PMID: 25639936
    4. Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters PMID: 25450959
    5. Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades. PMID: 25104077
    6. medial preoptic area galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses PMID: 24828191
    7. Analysis of the gene proximal region using EMSA and ChIP assays showed that CREB protein interacts with the galanin promoter both in vitro and in vivo. Additional EMSA analysis revealed that an SP1 consensus site mediated protein-DNA complex formation. PMID: 24487089
    8. The expression of mRNA galanin is increased following chronic restraint stress. PMID: 23639882
    9. These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression. PMID: 23583289
    10. extended perifornical area galanin-LepRb neurons galanin acts inhibitory rather than orexigenic PMID: 23482448
    11. The results suggest that neither galanin expression, nor the galanin-dependent subpopulation of sensory neurons is required for itch-related behaviours. PMID: 23216829
    12. Galanin transcript expression increased significantly in male mouse major pelvic ganglia neurons after 72 h in explant culture & 72 h after unilateral transection of the cavernous nerve. PMID: 22585545
    13. results indicate normal cholinergic responses and innervation of the sweat glands in galanin knockout mice, they also demonstrate that galanin plays a role in regulating the sudomotor activity in response to thermal stimulation PMID: 22698811
    14. GAL is a promising next-generation target for the treatment of MS. PMID: 22442732
    15. Galanin opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1 PMID: 21969124
    16. Subpopulations of kisspeptin neurons express galanin and met-enkephalin in the rostral periventricular region of the hypothalamus. PMID: 21800299
    17. These data showed that the galanin system is regulated by repeated electroconvulsive stimulation in brain regions involved in monoaminergic neurotransmission and stress modulation. PMID: 21820174
    18. examined the role of galanin signaling in nicotine reward by testing the effects of nicotine in mice lacking galanin peptide (GAL-/-) as compared to wild-type (GAL+/+) controls PMID: 21172385
    19. Galanin, a potent inhibitor of pancreatic bicarbonate secretion, is involved in the induction and progression of cerulein-induced experimental acute pancreatitis. PMID: 21160373
    20. Data show that the galanin system is regulated by repeated electroconvulsive stimulation in a number of brain regions implicated in seizure regulation and depression. PMID: 20936701
    21. results suggest the possible association of the galanin-mediated signaling pathways in the manifestation of the high-fat diet-induced activation of adipogenesis along with the suppression of thermogenesis in the adipose tissues PMID: 20183829
    22. Galanin is able to reduce neuropathic pain behaviour. PMID: 20964829
    23. Hypothalamic galanin peptides play a physiological role in stimulating the consumption of ethanol, as well as a fat-rich diet. PMID: 19860804
    24. Suggest a role for galanin in the pathogenesis of acute pancreatitis. PMID: 19959967
    25. These results obtained with overexpression of the GAL gene provide strong support for a physiological role of this peptide in stimulating the consumption of ethanol and a fat-rich diet. PMID: 20004335
    26. galanin knockout mice indicate that the peptide is critical to the development and function of neurons in the central and peripheral nervous system PMID: 11712539
    27. Galanin modulates anxiety states induced by high levels of noradrenaline;a specific role for galanin in anxiety states represents an attractive target for novel anxiolytic treatments. PMID: 11931346
    28. findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks PMID: 12177231
    29. upregulation of galanin in DRG neurones following nerve injury results in antinociception via stimulation of galanin GAL1 receptors and that the pro-nociceptive effect of galanin is related to GAL2 receptors on primary afferents--review PMID: 12368071
    30. Perinatal nicotine attenuates the hypoxia-induced up-regulation of galanin mRNA in locus ceruleus of the newborn mouse. PMID: 12409526
    31. neither hippocampal nor cortical galanin levels in the two cohorts of GAL-tg consistently correlated with performance across diverse cognitive tasks PMID: 12507436
    32. GAL inhibited TNF alpha release but not its mRNA levels in BV2 cells. GAL inhibits TNF alpha production by a post-transcriptional mechanism that both prevents the efficient addition of the poly(A) tail and accelerates TNF alpha mRNA degradation. PMID: 12507772
    33. Evidence is provided for an inhibitory function for the neuropeptide galanin acting on galanin receptor 1 (GALR1) in nociception and neuropathic pain after peripheral nerve injury in mice. PMID: 12605908
    34. data establish a new role for galanin as a hormone augmenting mammary development during pregnancy PMID: 12759342
    35. modulates behavioral and neurochemical signs of opiate withdrawal PMID: 12853567
    36. role of galanin in the regulation of release of NA and 5-HT in the hippocampus after forced swimming PMID: 14701907
    37. The unexpected obesity phenotype in galanin-neuropeptide Y double knockout mice may result from the dysregulation of the leptin and insulin systems that normally keep body weight within the homeostatic range. PMID: 15024085
    38. galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and galanin knockout mice have a reduced glucose-induced insulin secretion. PMID: 15044363
    39. Increased availability of galanin in spinal dorsal horn at the time or shortly after nerve injury may reduce the development of pain-like behaviors in mice. PMID: 15464755
    40. galanin may have a role in functions related to mood states including affective disorders PMID: 15582716
    41. mechanistic relationship between amyloidosis and GAL over expression in Alzheimer disease PMID: 15893372
    42. Lack of galanin-maintained cAMP tone in the galanin knockout mouse appears to result in a loss of negative feedback resulting in increased levels of CREB phosphorylation and increased GalR1 expression. PMID: 15934937
    43. estrogen receptors in trigeminal neurons modulate nociceptive responses through effects on galanin and NPY PMID: 15936815
    44. Mice overexpressing galanin had a moderate heat hypoalgesia, reduced spinal sensitization after repetitive C-fiber stimulation and reduced development of neuropathic pain-like behavior after sciatic nerve injury PMID: 15944013
    45. excess GAL in cognitive impairment is relevant to the overexpression of GAL in the basal forebrain during the progression of Alzheimer's disease PMID: 15944016
    46. galanin is involved in hippocampal synaptic plasticity, in particular in age-related reduction of synaptic plasticity in the lateral perforant path input to the dentate gyrus PMID: 15944020
    47. The highest levels of transgenic galanin expression were observed in the forebrain structures, in the mesencephalon, in the cerebellum, in the pons, and within the medulla oblongata PMID: 15944025
    48. galanin may have a role in functions related to mood states, including affective disorders PMID: 15944026
    49. overexpression of galanin can influence several behavioral and neurochemical parameters in old mice PMID: 15944027
    50. both Gal and NPY contribute to the prolonged attenuation of parasympathetic slowing of the heart following activation of the cardiac sympathetic nerve PMID: 15944033

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Galanin family
  • 数据库链接：

    KEGG: mmu:14419

    STRING: 10090.ENSMUSP00000025842

    UniGene: Mm.4655