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  4. Recombinant Mouse Fibrinogen-like protein 1 (Fgl1)

Recombinant Mouse Fibrinogen-like protein 1 (Fgl1)

  • 货号：
    CSB-YP741134MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP741134MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP741134MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP741134MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fgl1
  • Uniprot No.：
  • 别名：
    Fgl1; Mfire1; Fibrinogen-like protein 1; Fibrinogen-related protein 1; Mfrep-1; Liver fibrinogen-related protein-1; Mfire-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-314
  • 氨基酸序列
    LESESCLR EQVRLRAQVH QLETRVKQQQ TMIAQLLHEK EVQFLDKGSE NSFIDLGGKR QYADCSEIYN DGFKQSGFYK IKPLQSLAEF SVYCDMSDGG GWTVIQRRSD GSENFNRGWN DYENGFGNFV QNNGEYWLGN KNINLLTIQG DYTLKIDLTD FEKNSSFAQY QSFKVGDKKS FYELNIGEYS GTAGDSLSGT FHPEVQWWAS HQRMKFSTWD RDNDNYQGNC AEEEQSGWWF NRCHSANLNG VYYRGSYRAE TDNGVVWYTW HGWWYSLKSV VMKIRPSDFI PNII
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.
  • 基因功能参考文献：
    1. The results suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt-dependent mechanism and support its role as a potential therapeutic target in hepatocellular carcinoma. PMID: 26225745
    2. Hepassocin plays an important role in non-alcoholic fatty liver disease and induces hepatic lipid accumulation through an ERK1/2-dependent pathway. PMID: 23792031
    3. Fgl1 is a member of an emerging group of proteins with key roles in metabolism and liver regeneration. PMID: 23483972
    4. HNF1 binding site and HNF1alpha are critical to liver-specific expression of HPS, and down-regulation or loss of HNF1alpha causes, at least in part, the transcriptional down-regulation of HPS in HCC. PMID: 19304666
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Mainly expressed in liver. Also expressed in brown adipose tissue.
  • 数据库链接：

    KEGG: mmu:234199

    STRING: 10090.ENSMUSP00000034003

    UniGene: Mm.277955