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  4. Recombinant Mouse F-box/LRR-repeat protein 19 (Fbxl19)

Recombinant Mouse F-box/LRR-repeat protein 19 (Fbxl19)

  • 中文名称：
    小鼠Fbxl19重组蛋白
  • 货号：
    CSB-YP750842MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fbxl19重组蛋白
  • 货号：
    CSB-EP750842MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fbxl19重组蛋白
  • 货号：
    CSB-EP750842MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fbxl19重组蛋白
  • 货号：
    CSB-BP750842MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fbxl19重组蛋白
  • 货号：
    CSB-MP750842MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fbxl19
  • Uniprot No.：
  • 别名：
    Fbxl19; F-box/LRR-repeat protein 19; F-box and leucine-rich repeat protein 19
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-674
  • 氨基酸序列
    MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEDEKFSLS LMECTICNEI VHPGCLKMGK AEGVINSEIP NCWECPRCTQ EGRTSKDAGE GPGRRRADNG EEGANLGGGW KLTEEPPPPP PLPRRKGPLP AGPTPDDVPG PPKRKEREGG NEPPTPRKKV KGGRERHLKK VGGDACLLRG ADPGSPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPIA SAEGPAVPSP SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA RNGRRPARGS SGEKENRGGR RAIRPGTGGP LLSWPLGPAP PPRPPQLERH VVRPPPRSPE PDTLPLAAGS DHPLPRAAWL RVFQHLGPRE LCVCMRVCRT WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV VRRQPRALDL SWTGVSKKQL MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR WIEDVKDSQL RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR CPRLRRLDLR SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.
  • 基因功能参考文献：
    1. analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes PMID: 28611184
    2. SCF(FBXL19) targets RhoA for its disposal, a process regulated by Erk2. PMID: 23871831
    3. Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration. PMID: 23512198
    4. The fundamental observation was that FBXL19 attenuated IL-33-mediated activity by removing ST2L, but not sST2 or IL-1R1, on the cell surface. PMID: 22660580
  • 数据库链接：

    KEGG: mmu:233902

    STRING: 10090.ENSMUSP00000033081

    UniGene: Mm.259353