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  4. Recombinant Mouse Diencephalon/mesencephalon homeobox protein 1 (Dmbx1)

Recombinant Mouse Diencephalon/mesencephalon homeobox protein 1 (Dmbx1)

  • 中文名称：
    小鼠Dmbx1重组蛋白
  • 货号：
    CSB-YP838713MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dmbx1重组蛋白
  • 货号：
    CSB-EP838713MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dmbx1重组蛋白
  • 货号：
    CSB-EP838713MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dmbx1重组蛋白
  • 货号：
    CSB-BP838713MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dmbx1重组蛋白
  • 货号：
    CSB-MP838713MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dmbx1
  • Uniprot No.：
  • 别名：
    Dmbx1; Cdmx; Mbx; Otx3; PaxBDiencephalon/mesencephalon homeobox protein 1; Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein; Orthodenticle homolog 3; Paired-like homeobox protein DMBX1; Paired-type homeobox Atx
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-381
  • 氨基酸序列
    MQHYGVNGYS LHAMNSLSAM YNLHQQAAQQ AQHAPDYRPS VHALTLAERL AGCTFQDIIL EARYGSQHRK QRRSRTAFTA QQLEALEKTF QKTHYPDVVM RERLAMCTNL PEARVQVWFK NRRAKFRKKQ RSLQKEQLQK QKEAEGSHGE GKVEAPASDT QLETEQPPGL PSGDPPAELQ LSLSEQSASE SAPEDQLDRE EDSRAEEPKA EKSPGSESKV PGCKRGSPKA DSPGSLAITP AAPGGGLLGP SHSYSSSPLS LFRLQEQFRQ HMAATNNLMH YSSFEVGGPA PAAAAAAAAA VPYLGVNMAP LSSLHCQSYY QSLSAAAAAH QGVWGSPLLP APPTGLAPAS AALNSKTTSI ENLRLRAKQH AASLGLDTLP N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability.
  • 基因功能参考文献：
    1. The crystal structure of mouse ATX in complex with an anti-ATX aptamer. PMID: 27043297
    2. Data (including data from studies in transgenic/knockout mice) suggest that expression in adult brain neurons (especially in parabrachial nucleus) of both Dmbx1 and AgRP (agouti-related peptide) is important in appetite regulation leading to leanness. PMID: 26505115
    3. Dmbx1, a novel evolutionarily conserved paired-like homeobox gene is expressed in the brain of mouse embryos. Linkage analysis mapped mouse Dmbx1 to the mid-portion of chromosome 4. PMID: 11744391
    4. provides a useful molecular marker for early mouse midbrain development and may play a critical role in brain development PMID: 11914943
    5. results suggest that Otx3 is a novel member of the Otx family and may be involved in the development of the central nervous system PMID: 12055180
    6. Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development PMID: 12111214
    7. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum PMID: 12175514
    8. Dmbx1 is expressed only in the developing central nervous system and in particular during early determination and successive differentiation of the midbrain and caudal diencephalon PMID: 12175515
    9. Results demonstrate that Dmbx1 is required for postnatal survival, growth, and brain development. PMID: 15314164
    10. Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain PMID: 15890343
    11. Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior PMID: 17873059

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expressed in adult brain, stomach, and testis. Expressed in the developing diencephalon, midbrain and hindbrain. During limb development, expressed in a temporal pattern with expression being first restricted to the forelimbs and then subsequently to the
  • 数据库链接：

    KEGG: mmu:140477

    STRING: 10090.ENSMUSP00000120320

    UniGene: Mm.213206