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  4. Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4 (Cpeb4)

Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4 (Cpeb4)

  • 中文名称：
    Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4(Cpeb4),Yeast
  • 货号：
    CSB-YP742497MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4(Cpeb4),Yeast
  • 货号：
    CSB-EP742497MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4(Cpeb4),Yeast
  • 货号：
    CSB-EP742497MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4(Cpeb4),Yeast
  • 货号：
    CSB-BP742497MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytoplasmic polyadenylation element-binding protein 4(Cpeb4),Yeast
  • 货号：
    CSB-MP742497MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cpeb4
  • Uniprot No.：
  • 别名：
    Cpeb4; Kiaa1673Cytoplasmic polyadenylation element-binding protein 4; CPE-BP4; CPE-binding protein 4; mCPEB-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-729
  • 氨基酸序列
    MGDYGFGVLV QSNTGNKSAF PVRFHPHLQP PHHHQNATPN PAAFINNNTA ANGSSAGSAW LFPAPATHNI QDEILGSEKA KSQQQEQQDP LEKQQLSPSP GQEAGILPET EKAKAEENPG DSSSENSNGK EKLRIESPVL TGFDYQEATG LGTSTQPLTS SASSLTGFSN WSAAIAPSSS TIINEDASFF HQGGVPGASA NNGALLFQNF PHHVSPGFGG SFSPQIGPLS QHHPHHPHFQ HHHSQHQQQR RSPASPHPPP FTHRSAAFNQ LPHLANNLNK PPSPWSSYQS PSPTPSSSWS PGGGGYGGWG ASQGRDHRRG LNGGITPLNS ISPLKKNFAS NHIQLQKYAR PSSAFAPKSW MEDSLNRADN IFPFPERPRT FDMHSLESSL IDIMRAENDS IKGRLNYSYP GSDSSLLINA RTYGRRRGQS SLFPMEDGFL DDGRGDQPLH SGLGSPHCFT HQNGERVERY SRKVFVGGLP PDIDEDEITA SFRRFGPLIV DWPHKAESKS YFPPKGYAFL LFQDESSVQA LIDACIEEDG KLYLCVSSPT IKDKPVQIRP WNLSDSDFVM DGSQPLDPRK TIFVGGVPRP LRAVELAMIM DRLYGGVCYA GIDTDPELKY PKGAGRVAFS NQQSYIAAIS ARFVQLQHGE IDKRVEVKPY VLDDQLCDEC QGARCGGKFA PFFCANVTCL QYYCEYCWAA IHSRAGREFH KPLVKEGGDR PRHISFRWN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.
  • 基因功能参考文献：
    1. that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal granule cells PMID: 29166615
    2. Results show that Cpeb4 is highly expressed in the nervous system including spinal motor neurons. the CPEB4-unstructured low complexity domains (LCD) impairs neuron development that results in reduced motor axon branching and diminished NMJ formation in embryos and uncoordinated movement in neonatal mice. PMID: 27381259
    3. combined transcriptional and translational Cpeb4 regulation generates a 'circadian mediator', which coordinates hepatic UPR activity with periods of high ER-protein-folding demand PMID: 28092655
    4. Unlike its related family members, CPEB1 and CPEB3, CPEB4 seems to be dispensable for hippocampus-dependent plasticity, learning and memory. PMID: 24386439
    5. Cpeb4 is induced by Gata1 and Tal1, and is essential for terminal erythropoiesis. PMID: 25220394
    6. CPEB4 is expressed in the principal cell layers of the hippocampus PMID: 12871996

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  • 亚细胞定位：
    Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.
  • 蛋白家族：
    RRM CPEB family
  • 组织特异性：
    Highly expressed in brain, including hippocampus, amygdala, granule and Purkinje cells of the cerebellum (at protein level). Expressed in spinal cord (at protein level). Expressed in kidney, lung and heart (at protein level). Expressed in liver (at protei
  • 数据库链接：

    KEGG: mmu:67579

    STRING: 10090.ENSMUSP00000020543

    UniGene: Mm.339792