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  4. Recombinant Mouse Cytochrome P450 2C70 (Cyp2c70)

Recombinant Mouse Cytochrome P450 2C70 (Cyp2c70)

  • 中文名称：
    Recombinant Mouse Cytochrome P450 2C70(Cyp2c70),Yeast
  • 货号：
    CSB-YP820995MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 2C70(Cyp2c70),Yeast
  • 货号：
    CSB-EP820995MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 2C70(Cyp2c70),Yeast
  • 货号：
    CSB-EP820995MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 2C70(Cyp2c70),Yeast
  • 货号：
    CSB-BP820995MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 2C70(Cyp2c70),Yeast
  • 货号：
    CSB-MP820995MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cyp2c70
  • Uniprot No.：
  • 别名：
    Cyp2c70; Cyp2c-70; Cyp2c22; Cytochrome P450 2C70; EC 1.14.14.-; CYPIIC70
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-489
  • 氨基酸序列
    MALFIFLGIW LSCFLFLFLW NQHRGRGKLP PGPTPLPIVG NILQVDVKNI SKSMGMLAKK YGPVFTVYLG MKPTVVLHGY KAMKEALIDQ GDEFSDKTDS SLLSRTSQGL GIVFSNGETW KQTRRFSLMV LRSMGMGKKT IEDRIQEEIL YMLDALRKTN GSPCDPSFLL ACVPCNVIST VIFQHRFDYN DQTFQDFMEN FHRKIEILAS PWSQLCSAYP ILYYLPGIHN RFLKDVTQQK KFILEEINRH QKSLDLSNPQ DFIDYFLIKM EKEKHNQKSE FTMDNLVVSI GDLFGAGTET TSSTVKYGLL LLLKYPEVTA KIQEEIAHVI GRHRRPTMQD RNHMPYTDAV LHEIQRYIDF VPIPSPRKTT QDVEFRGYHI PKGTSVMACL TSVLNDDKEF PNPEKFDPGH FLDEKGNFKK SDYFVAFSAG RRACIGEGLA RMEMFLILTN ILQHFTLKPL VKPEDIDTKP VQTGLLHVPP PFELCFIPV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
  • 基因功能参考文献：
    1. Cyp2c70 is a primary enzyme responsible for alpha-muricholic acid production. PMID: 27638959
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    KEGG: mmu:226105

    STRING: 10090.ENSMUSP00000060584

    UniGene: Mm.29119