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  4. Recombinant Mouse C-type lectin domain family 12 member A (Clec12a), partial

Recombinant Mouse C-type lectin domain family 12 member A (Clec12a), partial

In Stock
  • 货号：
    CSB-BP709488MO
  • 规格：
    ￥3168
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Clec12a; MiclC-type lectin domain family 12 member A; C-type lectin-like molecule 1; CLL-1; Myeloid inhibitory C-type lectin-like receptor; MICL; CD antigen CD371
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    Baculovirus
  • 分子量：
    27.8 kDa
  • 表达区域：
    65-267aa
  • 氨基酸序列
    YTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • 基因功能参考文献：
    1. The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS. PMID: 28578388
    2. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting PMID: 27978488
    3. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo. PMID: 26095365
    4. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. PMID: 24631154
    5. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
    6. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
    7. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
    8. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 数据库链接：

    KEGG: mmu:232413

    STRING: 10090.ENSMUSP00000063627

    UniGene: Mm.90241