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  4. Recombinant Mouse Autophagy-related protein 13 (Atg13)

Recombinant Mouse Autophagy-related protein 13 (Atg13)

  • 货号：
    CSB-YP849680MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP849680MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP849680MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP849680MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP849680MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Atg13; D2Ertd391e; Kiaa0652; Autophagy-related protein 13
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-516
  • 氨基酸序列
    METELSSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW FNLAIKDIPE VTHEAKKALS GQLPAVGRSM CVEISLKTSE GDSMELEIWC LEMNEKCDKE IKVSYTVYNR LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI LYRIYFGEVQ LNGLGEGFQT VRVGTVGTPV GTLTLSCAYR INLAFMSTRQ FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAEDAGVA YPSVEDSQEV CTTSFSTSPP SQLSSSRLSY QPAVLGLGSA DLAYPVVFTA GLNTTHAHQL MVPGKEGGVT LAPSHPTHGA QADPERLVMH MPSDGTHCAA TPSSSEDTET VSNSSEGRAS PHDILETIFV RKVGAFVNKP INQVTVTSLD IPFAMFAPKN LELEDADPMV NPPESPETTS PLHGSLHSDG SSGGSGGSTH DDFVMIDFKP AFSKDDILPM DLGTFYREFQ NPPQLSSLSI DFGAQSMAED LDSLPEKLAV HEKNVREFDA FVETLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
  • 基因功能参考文献：
    1. ATG13 phosphorylation plays a crucial role in autophagy regulation. PMID: 26801615
    2. Atg13-deficient embryos show growth retardation and myocardial growth defects. PMID: 26644405
  • 亚细胞定位：
    Cytoplasm, cytosol. Preautophagosomal structure.
  • 蛋白家族：
    ATG13 family, Metazoan subfamily
  • 数据库链接：

    KEGG: mmu:51897

    UniGene: Mm.28492