Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Agouti-signaling protein (Asip)

Recombinant Mouse Agouti-signaling protein (Asip)

  • 货号：
    CSB-YP002212MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002212MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002212MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002212MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002212MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Asip; aAgouti-signaling protein; ASP; Agouti coat color protein; Agouti switch protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-131
  • 氨基酸序列
    HLALEETL GDDRSLRSNS SMNSLDFSSV SIVALNKKSK KISRKEAEKR KRSSKKKASM KKVARPPPPS PCVATRDSCK PPAPACCDPC ASCQCRFFGS ACTCRVLNPN C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth.
  • 基因功能参考文献：
    1. The data confirm development of obesity and disturbance of lipid metabolism in Ay males. There were no changes in testicular function. PMID: 30188668
    2. Methylation analysis reveals that although most lines display normal methylation at IAP elements in general, the Avy IAP element is essentially unmethylated. PMID: 25191835
    3. observed variable histone patterns in the 5' long terminal repeat of the viable yellow agouti (A(vy)) metastable epiallele PMID: 20671424
    4. Data suggest that that the agouti/melanocortin signaling pathway regulates levels of peroxisome proliferator activated receptor gamma in adipocytes. PMID: 12851309
    5. AP overproduction increased the response of the pituitary adrenal system to short-restraint stress due to increased adrenal responsiveness to ACTH PMID: 15296483
    6. Local long-term mouse Agouti expression in the PVN, DMH, and LH differentially induced hyperphagia and accelerated body weight gain without apparent changes in central neuropeptide systems that are known to stimulate food intake in rats. PMID: 15537888
    7. mice with different agouti genotypes had identical basal corticosterone levels, though yellow mice, as compared with black mice, had increased corticosterone levels after restriction stress PMID: 15779332
    8. Corin plays a critical role in specifying coat color and acts downstream of agouti gene expression as a suppressor of the agouti pathway. PMID: 18057101
    9. The preimplantation embryo's growth environment can affect the postnatal expression of a defined epigenetically sensitive allele. PMID: 18562706
    10. pigment-related genes targeted by ASP and by alphaMSH PMID: 19174519
    11. study shows ASIP-MC1R signaling includes a cAMP-independent pathway through attractin and mahogunin, while the known cAMP-dependent component requires neither attractin nor mahogunin PMID: 19493315
    12. effects of the A(y) allele on mandible morphology on different strain backgrounds, DDD and B6 PMID: 19644225

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Epithelial cells of the hair follicles and the epidermis.
  • 数据库链接：

    KEGG: mmu:50518

    STRING: 10090.ENSMUSP00000029123

    UniGene: Mm.315593