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  4. Recombinant Mouse Achaete-scute homolog 2 (Ascl2)

Recombinant Mouse Achaete-scute homolog 2 (Ascl2)

  • 中文名称：
    Recombinant Mouse Achaete-scute homolog 2(Ascl2),Yeast
  • 货号：
    CSB-YP002200MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Achaete-scute homolog 2(Ascl2),Yeast
  • 货号：
    CSB-EP002200MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Achaete-scute homolog 2(Ascl2),Yeast
  • 货号：
    CSB-BP002200MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Achaete-scute homolog 2(Ascl2),Yeast
  • 货号：
    CSB-MP002200MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ascl2
  • Uniprot No.：
  • 别名：
    Ascl2; Mash2Achaete-scute homolog 2; ASH-2; mASH-2; mASH2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MEAHLDWYGV PGLQEASDAC PRESCSSALP EAREGANVHF PPHPVPREHF SCAAPELVAG AQGLNASLMD GGALPRLMPT SSGVAGACAA RRRQASPELL RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALAGGLLT PATPPSDECA QPSASPASAS LSCASTSPSP DRLGCSEPTS PRSAYSSEES SCEGELSPME QELLDFSSWL GGY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
  • 基因功能参考文献：
    1. Ascl2 inhibits myogenic differentiation by targeting MRFs and facilitates the generation of postnatal satellite cells. PMID: 27993983
    2. overexpression of the imprinted Ascl2 gene has considerable consequences for placental development, specifically for the parietal trophoblast giant cell and spongiotrophoblast lineages both of which express pregnancy-related hormones. PMID: 27542691
    3. The ascl2 forms a transcriptional switch that is both Wnt responsive and Wnt dependent to define stem cell identity. PMID: 25620640
    4. Ascl2 directly initiates follicular T-helper cell development PMID: 24463518
    5. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway. PMID: 23071113
    6. Elevated expression of Ascl2 in a Wnt signalling dependent manner specifically in the stem cell compartment of the intestine neither increases tumour formation nor diminishes survival in a well established intestinal tumour model, the Apc(min) mouse. PMID: 22138533
    7. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells PMID: 22384170
    8. Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction. PMID: 21238448
    9. Mash2 gene is preferentially expressed from the paternal allele. PMID: 7773285
    10. Mash2 is a regulator of Krox24, Mob-1, and CXCR4 expression in cultured Schwann cells and negatively regulates their proliferation; a candidate for missing class B bHLH proteins in peripheral nerves PMID: 12196582
    11. structure of the Mash2 gene and placental Mash2 expression at different gestational ages PMID: 12493693
    12. ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia PMID: 16568095
    13. The combined results from these gain- and loss-of-function experiments imply that Ascl2 controls intestinal stem cell fate. PMID: 19269367

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:17173

    STRING: 10090.ENSMUSP00000009392

    UniGene: Mm.196417