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  4. Recombinant Human dCTP pyrophosphatase 1 (DCTPP1)

Recombinant Human dCTP pyrophosphatase 1 (DCTPP1)

  • 货号：
    CSB-YP006570HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006570HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP006570HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006570HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006570HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CDA03 ; dCTP pyrophosphatase 1; DCTP1_HUMAN; dCTPase 1; DCTPP1; Deoxycytidine triphosphatase 1; Deoxycytidine-triphosphatase 1; RS21C6; XTP3 transactivated gene A protein; XTP3 transactivated protein A; XTP3-transactivated gene A protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-170
  • 氨基酸序列
    SVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF HQPRNLLLAL VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL IYLVALAARC RVDLPLAVLS KMDINRRRYP AHLARSSSRK YTELPHGAIS EDQAVGPADI PCDSTGQTST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
  • 基因功能参考文献：
    1. DCTPP1 may play an important role in PCa progression associated with high autophagy PMID: 29874556
    2. Hypermethylation of CpG islands in MDR1 gene promoter region is obvious in DCTPP1-knockdown BGC-823 gastric cancer (GC) cells. PMID: 27612427
    3. DCTPP1 has a central role in the balance of dCTP and the metabolism of deoxycytidine analogues. PMID: 24467396
    4. Human dCTP pyrophosphatase 1 binds and is inhibited by the small molecule triptolide in vitro. PMID: 21671327
  • 亚细胞定位：
    Mitochondrion. Nucleus. Cytoplasm, cytosol.
  • 数据库链接：

    HGNC: 28777

    OMIM: 615840

    KEGG: hsa:79077

    STRING: 9606.ENSP00000322524

    UniGene: Hs.632191