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  4. Recombinant Human Zygote arrest protein 1 (ZAR1)

Recombinant Human Zygote arrest protein 1 (ZAR1)

  • 货号：
    CSB-YP803109HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803109HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803109HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803109HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803109HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZAR1
  • Uniprot No.：
  • 别名：
    Oocyte-specific maternal effect factor; zar1; ZAR1_HUMAN; zygote arrest 1; Zygote arrest protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-424
  • 氨基酸序列
    MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA SSPCSAGAAS LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR AGSCDVAVQV SPRIDAAVQC SLGRRTLQRR ARDPESPAGP GAEGTTGGGS FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA VYSPLALRRL TAFLEGPGPA AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD DDGEAQAAVR ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT NKVYFKQFCR TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR QDLCGRCKGK RLSCDSTFSF KYII
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for female fertility. May play a role in the oocyte-to-embryo transition.
  • 基因功能参考文献：
    1. ZAR1 has oncogenic effects in neuroblastoma by suppressing cell differentiation via regulation of MYCN expression.Elevated ZAR1 expression level is closely related to poor prognosis of patients with neuroblastoma. PMID: 28791558
    2. Study shows for the first time the lung tumor-specific epigenetic inactivation of ZAR1 due to DNA methylation of its CpG island promoter. Furthermore, ZAR1 was characterized by the ability to block tumor growth through the inhibition of cell cycle progression in cancer cell lines. PMID: 28588743
    3. A decreased methylation level at CpG sites of ZAR1 exon 1/intron 1. CpGi could serve as a biomarker for invasive bladder cancer. PMID: 25227574
    4. ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis PMID: 24787227
    5. Hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome. PMID: 23583134
    6. Findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis. PMID: 21206179
    7. we identified a frequently aberrant methylated region within the Zygote arrest 1 (ZAR1) gene in melanoma and demonstrated a distinct methylation pattern between melanoma and nevus.The involvement of ZAR1 in the carcinogenesis of melanoma remains unclear. PMID: 20654783
    8. The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life. PMID: 12773403
    9. Zygote arrest 1 (ZAR1) could be implicated in regulation of meiosis and post meiotic differentiation of male and female germ cells through expression of shorter splicing variants. Central role of this gene in early reproductive processes. PMID: 16551357

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    ZAR1 family
  • 组织特异性：
    Ovary and testis.
  • 数据库链接：

    HGNC: 20436

    OMIM: 607520

    KEGG: hsa:326340

    STRING: 9606.ENSP00000329803

    UniGene: Hs.276457