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  4. Recombinant Human Unique cartilage matrix-associated protein (UCMA)

Recombinant Human Unique cartilage matrix-associated protein (UCMA)

  • 中文名称：
    人UCMA重组蛋白
  • 货号：
    CSB-YP855482HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UCMA重组蛋白
  • 货号：
    CSB-EP855482HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UCMA重组蛋白
  • 货号：
    CSB-EP855482HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UCMA重组蛋白
  • 货号：
    CSB-BP855482HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UCMA重组蛋白
  • 货号：
    CSB-MP855482HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UCMA
  • Uniprot No.：
  • 别名：
    UCMA; C10orf49; Unique cartilage matrix-associated protein [Cleaved into: Unique cartilage matrix-associated protein C-terminal fragment; Ucma-C; Gla-rich protein; GRP)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-138
  • 氨基酸序列
    VSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR QWHYDGLHPS YLYNRHHT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.
  • 基因功能参考文献：
    1. GRP might act as a novel molecular mediator linking inflammation and calcification events PMID: 28542410
    2. The study demonstrates the involvement of GRP in the two major molecular processes affecting osteoarthritis: mineralization and inflammation of articular tissue. PMID: 26337479
    3. Data suggest that novel splice variants of GRP are expressed in cartilage and other tissues (i.e. GRP-F5, GRP-F6); GRP-F1 is predominant splice variant expressed in adult tissues particularly in cartilage of patients with osteoarthritis. PMID: 24867294
    4. full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population PMID: 24409676
    5. Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla residues. PMID: 18836183
    6. The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation. PMID: 17707622
    7. Ucma may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells PMID: 18156182

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    UCMA family
  • 组织特异性：
    Predominantly expressed in resting chondrocytes.
  • 数据库链接：

    HGNC: 25205

    KEGG: hsa:221044

    STRING: 9606.ENSP00000367952

    UniGene: Hs.112998