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  4. Recombinant Human Tripartite motif-containing protein 44 (TRIM44)

Recombinant Human Tripartite motif-containing protein 44 (TRIM44)

  • 中文名称：
    人TRIM44重组蛋白
  • 货号：
    CSB-YP836200HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TRIM44重组蛋白
  • 货号：
    CSB-EP836200HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TRIM44重组蛋白
  • 货号：
    CSB-EP836200HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TRIM44重组蛋白
  • 货号：
    CSB-BP836200HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TRIM44重组蛋白
  • 货号：
    CSB-MP836200HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIM44
  • Uniprot No.：
  • 别名：
    AN3; DIPB; HSA249128; MC7 ; MGC3490; Protein DIPB; TRI44_HUMAN; TRIM44; Tripartite motif containing 44; Tripartite motif containing protein 44; Tripartite motif-containing protein 44
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-344
  • 氨基酸序列
    MASGVGAAFE ELPHDGTCDE CEPDEAPGAE EVCRECGFCY CRRHAEAHRQ KFLSHHLAEY VHGSQAWTPP ADGEGAGKEE AEVKVEQERE IESEAGEESE SEEESESEEE SETEEESEDE SDEESEEDSE EEMEDEQESE AEEDNQEEGE SEAEGETEAE SEFDPEIEME AERVAKRKCP DHGLDLSTYC QEDRQLICVL CPVIGAHQGH QLSTLDEAFE ELRSKDSGGL KAAMIELVER LKFKSSDPKV TRDQMKMFIQ QEFKKVQKVI ADEEQKALHL VDIQEAMATA HVTEILADIQ SHMDRLMTQM AQAKEQLDTS NESAEPKAEG DEEGPSGASE EEDT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the process of differentiation and maturation of neuronal cells. May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression.
  • 基因功能参考文献：
    1. The levels of TRIM44 protein and TRIM44 mRNA in squamous cell carcinoma are both lowly expressed which is strongly associated with tumor staging, metastasis, and poor survival. PMID: 30383661
    2. Elevated TRIM44 expression promotes human esophageal cancer development by epithelial mesenchymal transition via the AKT/mTOR pathway. PMID: 30098109
    3. that TRIM44 predicts the risk of development and prognosis of endometrial cancer, highlighting its potential application as a therapeutic target for this malignancy PMID: 29526558
    4. Silencing of TRIM44 inhibits the proliferation, migration and invasion of papillary thyroid cancer cells. PMID: 28965013
    5. Mechanistic studies showed that knockdown of TRIM44 significantly reduced the levels of phosphorylated PI3K and Akt in PC-3 cells. Study provided evidence that knockdown of TRIM44 inhibited proliferation and invasion in prostate cancer cells, at least in part, through the inactivation of the PI3K/Akt signaling pathway. PMID: 28160462
    6. the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. PMID: 28885545
    7. Data show that the TRIM44-mTOR axis increases metastasis and proliferation. PMID: 27058415
    8. These results suggest that tripartite motif-containing protein 44 protein could play a crucial role in tumor invasion through its overexpression and highlight its usefulness as a predictor and potential therapeutic target in esophageal squamous cell carcinoma PMID: 28618928
    9. results suggest that high expression of TRIM44 is associated with poor prognosis and that TRIM44 plays significant role in cell proliferation, migration, and anti-apoptosis in testicular germ cell tumor PMID: 27754579
    10. High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma. PMID: 27619678
    11. Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression PMID: 26394807
    12. Trim44 promotes non-small cell lung cancer development through activation of NF-kappaB signaling via upregulating CXCL16 and MMP9 expression. PMID: 25345539
    13. rim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA. PMID: 23460740
    14. Overexpression of the TRIM44 protein was significantly correlated with an advanced type of macroscopic appearance. PMID: 22862969
    15. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein. PMID: 19358823

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  • 相关疾病：
    Aniridia 3 (AN3)
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 19016

    OMIM: 612298

    KEGG: hsa:54765

    STRING: 9606.ENSP00000299413

    UniGene: Hs.192103