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  4. TRIM44 Antibody

TRIM44 Antibody

  • 中文名称：
    TRIM44兔多克隆抗体
  • 货号：
    CSB-PA024482GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96DX7
  • 基因名：
    TRIM44
  • 别名：
    AN3 antibody; DIPB antibody; HSA249128 antibody; MC7 antibody; MGC3490 antibody; Protein DIPB antibody; TRI44_HUMAN antibody; TRIM44 antibody; Tripartite motif containing 44 antibody; Tripartite motif containing protein 44 antibody; Tripartite motif-containing protein 44 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRIM44
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in the process of differentiation and maturation of neuronal cells. May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression.
  • 基因功能参考文献：
    1. The levels of TRIM44 protein and TRIM44 mRNA in squamous cell carcinoma are both lowly expressed which is strongly associated with tumor staging, metastasis, and poor survival. PMID: 30383661
    2. Elevated TRIM44 expression promotes human esophageal cancer development by epithelial mesenchymal transition via the AKT/mTOR pathway. PMID: 30098109
    3. that TRIM44 predicts the risk of development and prognosis of endometrial cancer, highlighting its potential application as a therapeutic target for this malignancy PMID: 29526558
    4. Silencing of TRIM44 inhibits the proliferation, migration and invasion of papillary thyroid cancer cells. PMID: 28965013
    5. Mechanistic studies showed that knockdown of TRIM44 significantly reduced the levels of phosphorylated PI3K and Akt in PC-3 cells. Study provided evidence that knockdown of TRIM44 inhibited proliferation and invasion in prostate cancer cells, at least in part, through the inactivation of the PI3K/Akt signaling pathway. PMID: 28160462
    6. the TRIM44 status was an independent prognostic factor for distant disease-free survival (p = 0.005) and overall survival (p = 0.002) of patients. PMID: 28885545
    7. Data show that the TRIM44-mTOR axis increases metastasis and proliferation. PMID: 27058415
    8. These results suggest that tripartite motif-containing protein 44 protein could play a crucial role in tumor invasion through its overexpression and highlight its usefulness as a predictor and potential therapeutic target in esophageal squamous cell carcinoma PMID: 28618928
    9. results suggest that high expression of TRIM44 is associated with poor prognosis and that TRIM44 plays significant role in cell proliferation, migration, and anti-apoptosis in testicular germ cell tumor PMID: 27754579
    10. High expression of TRIM44 is associated with enhanced cell proliferation, migration, invasion, and resistance to doxorubicin in hepatocellular carcinoma. PMID: 27619678
    11. Variants in TRIM44 Cause Aniridia by Impairing PAX6 Expression PMID: 26394807
    12. Trim44 promotes non-small cell lung cancer development through activation of NF-kappaB signaling via upregulating CXCL16 and MMP9 expression. PMID: 25345539
    13. rim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA. PMID: 23460740
    14. Overexpression of the TRIM44 protein was significantly correlated with an advanced type of macroscopic appearance. PMID: 22862969
    15. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein. PMID: 19358823

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  • 相关疾病：
    Aniridia 3 (AN3)
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 19016

    OMIM: 612298

    KEGG: hsa:54765

    STRING: 9606.ENSP00000299413

    UniGene: Hs.192103