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  4. Recombinant Human Target of EGR1 protein 1 (TOE1)

Recombinant Human Target of EGR1 protein 1 (TOE1)

  • 中文名称：
    人TOE1重组蛋白
  • 货号：
    CSB-YP856942HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TOE1重组蛋白
  • 货号：
    CSB-EP856942HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TOE1重组蛋白
  • 货号：
    CSB-EP856942HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TOE1重组蛋白
  • 货号：
    CSB-BP856942HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TOE1重组蛋白
  • 货号：
    CSB-MP856942HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TOE1
  • Uniprot No.：
  • 别名：
    Target of EGR1 protein 1; target of EGR1; member 1 ; Toe1; TOE1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-510
  • 氨基酸序列
    AADSDDGAV SAPAASDGGV SKSTTSGEEL VVQVPVVDVQ SNNFKEMWPS LLLAIKTANF VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSILSL GLACFKRQPD KGEHSYLAQV FNLTLLCMEE YVIEPKSVQF LIQHGFNFNQ QYAQGIPYHK GNDKGDESQS QSVRTLFLEL IRARRPLVLH NGLIDLVFLY QNFYAHLPES LGTFTADLCE MFPAGIYDTK YAAEFHARFV ASYLEYAFRK CERENGKQRA AGSPHLTLEF CNYPSSMRDH IDYRCCLPPA THRPHPTSIC DNFSAYGWCP LGPQCPQSHD IDLIIDTDEA AAEDKRRRRR RREKRKRALL NLPGTQTSGE AKDGPPKKQV CGDSIKPEET EQEVAADETR NLPHSKQGNK NDLEMGIKAA RPEIADRATS EVPGSQASPN PVPGDGLHRA GFDAFMTGYV MAYVEVSQGP QPCSSGPWLP ECHNKVYLSG KAVPLTVAKS QFSRSSKAHN QKMKLTWGSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.
  • 基因功能参考文献：
    1. Human cells with reduced levels of TOE1 accumulated 3'-end-extended pre-snRNA. PMID: 28092684
    2. Antiviral potency of TOE1 and its cell-penetrating capability have been identified to lie within a 35-amino-acid region containing the nuclear localization sequence PMID: 26056259
    3. TOE1 has a role in the growth inhibitory activity of Egr1 PMID: 12562764
  • 相关疾病：
    Pontocerebellar hypoplasia 7 (PCH7)
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles.
  • 蛋白家族：
    CAF1 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 15954

    OMIM: 613931

    KEGG: hsa:114034

    STRING: 9606.ENSP00000361162

    UniGene: Hs.525091