Recombinant Human Signal transducer and activator of transcription 1-alpha/beta (STAT1)

1. we suggest that STAT1HDAC4 signaling induces malignant tumor features such as EMT and sphere formation in CUG2overexpressing cancer cells. PMID: 30226605
2. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. PMID: 30018336
3. High STAT1 expression is associated with Melanoma. PMID: 29150430
4. These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 in human BM and WJMSCs were mediated by STAT1 signaling, and not by PI3K/RACalpha serine/threonineprotein kinase signaling PMID: 29901104
5. STAT1 plays a pivotal role as a tumor suppressor in glioma. PMID: 29800921
6. the present study revealed a negative correlation between the expression of the STAT-1 gene and the glioma grade, as well as between STAT-1 and mutant p53 expression. The negative correlation between STAT-1 and the pathological level of glioma suggested that STAT-1 may be associated with the occurrence and development of glioma, and may be a diagnostic biomarker and therapeutic target for the malignancy of glioma. PMID: 29620180
7. PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells PMID: 27796300
8. PVT1 interacts with STAT1 to inhibit IFN-alpha signaling and tumor cells proliferation. PMID: 29715456
9. STAT1 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence PMID: 29651441
10. High STAT1 expression is associated with head and neck squamous cell carcinoma. PMID: 29328389
11. The research described here specifies where in the JAK/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds. PMID: 29925658
12. These results reveal that STAT1 pS727 regulates growth and differentiation in JAK-STAT activated neoplasms and suggest that Mediator kinase inhibition represents a therapeutic strategy to regulate JAK-STAT signaling PMID: 29239838
13. Transcription factor STAT1 regulates the expression of LINC00174 PMID: 29729381
14. Dysregulation of the IFN-gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia PMID: 29474442
15. STAT1b plays a key role in enhancing the tumor suppressor function of STAT1a, in ESCC, in a manner that can be amplified by IFN-gamma PMID: 28981100
16. HSP90 is an upstream regulator of the ACK1-dependent phosphorylation of STAT1 and STAT3. PMID: 28739485
17. These findings suggest that IFN-a can inhibit HCV replication through a STAT2-dependent but STAT1-independent pathway, whereas IFN-g induces ISG expression and inhibits HCV replication exclusively through a STAT1- and STAT2-dependent pathway. PMID: 27929099
18. MxA inhibits hepatitis C virus replication through JAK-STAT pathway activation. PMID: 29417241
19. These results indicate the potential involvement of STAT1 in the regulation of trophoblast behavior. Furthermore, STAT 1 functions are more efficiently inhibited by blocking its expression than its phosphorylation. PMID: 28552376
20. s detected the ERK, p-ERK and STAT1 expression in 131 ESCC cases and 22 case-matched normal esophageal tissues adjacent to the tumors specimens. These findings provide pathological evidence that ERK/p-ERK is negatively correlated with STAT1 in ESCC. PMID: 28431406
21. 129:Stat1 (-/-) is a unique model for studying the critical origins and risk reduction strategies in age-related ER(+) breast cancer. In addition, it can be used in preclinical trials of hormonal and targeted therapies as well as immunotherapies. PMID: 28865492
22. STAT1 knockdown using an inhibitor and siRNA attenuated the IL-17-mediated increases in IL-6, IL-8 and VEGF expression in A549 and H292 cells. PMID: 27819281
23. Review of the role of STAT1 and STAT3 gain-of-function mutations in primary immunodeficiency/immunodysregulation disorders. PMID: 28914637
24. IFN gamma induced upregulation of BCL6 was dependent on the classical STAT1 signaling pathway, and affected both major BCL6 variants. Interestingly, although IFN alpha induced stronger STAT1 phosphorylation than IFN gamma, it only slightly upregulated BCL6 in multiple myeloma lines. PMID: 29510136
25. this study shows that miR-146a negatively regulates NK cell functions via STAT1 signaling PMID: 26996068
26. s found that YY1 and STAT1 were upregulated in ox-LDL-stimulating macrophages followed by translocation in the nucleus and binding to the transcriptional promoter region of miR-29a, thus leading to the increase of miR-29a expression. PMID: 28593745
27. Candidate biomarker genes such as CXCL10, IRF1, STAT1, IFIT2, and IFIT3 may be suitable therapeutic targets for ICM. PMID: 28150292
28. Aberrant Th1 immune responses in biliary atresia promote the proliferation and secretion of hepatic stellate cells through the IFN-gamma/STAT1 pathway. PMID: 28304404
29. Calcitriol treatment of the TL-1 cell line (model of T-LGLL) led to decreased phospho-Y701 STAT1 and phospho-Y705 STAT3 and increased vitamin D receptor (VDR) levels. PMID: 27715403
30. These findings indicate that viral replication and inflammation are linked through a common IFNgamma-like, STAT-dependent pathway and that HIV-1-induced STAT1 and STAT3 signaling are involved in both inflammation and HIV-1 replication. PMID: 28142265
31. Increased levels of STAT1 Protein in CD4 T-cells from systemic lupus erythematosus patients are associated with disease severity. PMID: 28256939
32. miR203 acts as a tumor suppressor in glioblastoma by suppressing the pro-tumorigenic action of STAT1. PMID: 27705947
33. Results show that high ph-STAT1 and ph-STAT3 tumor cell expression were associated with increased ER and PR, reduced tumor grade and necrosis. STAT1 and STAT3 expression appeared to be an important determinant of favorable outcome in patients with invasive ductal breast cancer suggesting that both act as tumor suppressor proteins in patients with ductal breast cancer. PMID: 27769057
34. Results identified STAT1 as a central node of tumor-stimulated stromal signature and demonstrate that stromal STAT1 expression promotes tumor progression. PMID: 28108623
35. The results of the present study indicate that ISTP may inhibit TARC/CCL17 production in human epidermal keratinocytes via the STAT1 signaling pathway and may be associated with the inhibition of IL33 production. PMID: 28447741
36. In human gastrointestinal stromal tumors (GIST) cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 via STAT1 inhibition. PD-1/PD-L1 blockade is a promising strategy to improve the effects of targeted therapy in GISTs PMID: 27470968
37. STAT3/STAT1 ratios are better clinical predictors in colorectal carcinoma as compared to STAT3 or STAT1 levels alone. PMID: 27191495
38. In a subgroup of Schizophrenic patients, blood levels of STAT1 were significantly higher compared to the control group. PMID: 27820940
39. Suggest a positive feedback mechanism via the STAT1/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK/STAT in TNFalpha-mediated senescence. PMID: 29176033
40. our findings suggested that OSM suppresses SLUG expression and tumor metastasis of lung adenocarcinoma cells through inducing the inhibitory effect of the STAT1-dependent pathway and suppressing the activating effect of STAT3-dependent signaling PMID: 27486982
41. miR-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta signalling via STAT1/SOCS3. PMID: 28622443
42. The phosphorylation of STAT1 promotes its binding to TRADD, and thus recruits Fas-associated protein with DD (FADD) and caspase 8 to form DISC complexes. PMID: 28186502
43. The results demonstrate that cystatin B interferes with the STAT-1 signaling and IFN-beta-antiviral responses perpetuating HIV in macrophage reservoirs. PMID: 27137788
44. propose that one molecule of C protein associates with the STAT1:STAT2 heterodimer, inducing a conformational change to an antiparallel form, which is easily dephosphorylated PMID: 28978648
45. Transfections of undifferentiated shed cells with miR-450a-5p or miR-28-5p mimics or with miR-450a-5p or miR-28-5p antagonists demonstrated that these miRNAs might play a role as posttranscriptional controllers of STAT1 mRNA during osteoblastic differentiation. PMID: 28407302
46. Data indicate that dysregulated IFN-gamma secretion by NK cells contributed to a significant defect in STAT1 in patients with advanced melanoma in response to IL-2 stimulation. PMID: 27153543
47. our results first identified that the proper increase of PD-1/STAT1 may contribute to hematopoietic improvement and prolonged survival in lower risk MDS. Our study proposed that the PD-1-related strategy to treat MDS should be different for lower risk patients than it is for those with highly progressive characteristics. PMID: 27686004
48. findings shed new light on the STAT1/miR-181a/PTEN pathway in colorectal cancer and add new insight regarding the carcinogenesis of colorectal cancer. PMID: 28322462
49. In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation. PMID: 28262979
50. Decreased phosphorylated STAT1 expression was accompanied by increased replication of hepatitis C virus and hepatitis E virus. PMID: 28442624

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HGNC: 11362

OMIM: 600555

KEGG: hsa:6772

STRING: 9606.ENSP00000354394

UniGene: Hs.642990