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  4. Recombinant Human Serine/threonine-protein kinase 17B (STK17B)

Recombinant Human Serine/threonine-protein kinase 17B (STK17B)

  • 货号：
    CSB-YP022838HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022838HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022838HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022838HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022838HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STK17B
  • Uniprot No.：
  • 别名：
    DAP kinase related apoptosis inducing protein; DAP kinase related apoptosis inducing protein kinase 2; DAP kinase-related apoptosis-inducing protein kinase 2; Death associated protein kinase related 2 ; DRAK 2; DRAK2; Serine/threonine kinase 17b; Serine/threonine kinase 17b apoptosis inducing ; Serine/threonine protein kinase 17B ; Serine/threonine-protein kinase 17B; ST17B_HUMAN; STK 17B; Stk17b
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-372
  • 氨基酸序列
    MSRRRFDCRS ISGLLTTTPQ IPIKMENFNN FYILTSKELG RGKFAVVRQC ISKSTGQEYA AKFLKKRRRG QDCRAEILHE IAVLELAKSC PRVINLHEVY ENTSEIILIL EYAAGGEIFS LCLPELAEMV SENDVIRLIK QILEGVYYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF GMSRKIGHAC ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN QETYLNISQV NVDYSEETFS SVSQLATDFI QSLLVKNPEK RPTAEICLSH SWLQQWDFEN LFHPEETSSS SQTQDHSVRS SEDKTSKSSC NGTCGDREDK ENIPEDSSMV SKRFRFDDSL PNPHELVSDL LC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.
  • 基因功能参考文献：
    1. ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
    2. DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
    3. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
    4. DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
    5. Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
    6. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987

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  • 亚细胞定位：
    Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
  • 组织特异性：
    Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
  • 数据库链接：

    HGNC: 11396

    OMIM: 604727

    KEGG: hsa:9262

    STRING: 9606.ENSP00000263955

    UniGene: Hs.88297