STK17B Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) STK17B Polyclonal antibody
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Uniprot No.:O94768
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基因名:STK17B
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别名:DAP kinase related apoptosis inducing protein antibody; DAP kinase related apoptosis inducing protein kinase 2 antibody; DAP kinase-related apoptosis-inducing protein kinase 2 antibody; Death associated protein kinase related 2 antibody; DRAK 2 antibody; DRAK2 antibody; Serine/threonine kinase 17b antibody; Serine/threonine kinase 17b apoptosis inducing antibody; Serine/threonine protein kinase 17B antibody; Serine/threonine-protein kinase 17B antibody; ST17B_HUMAN antibody; STK 17B antibody; Stk17b antibody
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宿主:Rabbit
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反应种属:Human, Mouse
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免疫原:Recombinant Human Serine/threonine-protein kinase 17B protein (235-366AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,STK17B Antibody (CSB-PA022838LA01HU),的标记方式是Non-conjugated。对于STK17B Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:200-1:500 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.
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基因功能参考文献:
- ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
- DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
- DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
- DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
- Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
- Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987
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亚细胞定位:Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.
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蛋白家族:Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
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组织特异性:Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
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数据库链接:
HGNC: 11396
OMIM: 604727
KEGG: hsa:9262
STRING: 9606.ENSP00000263955
UniGene: Hs.88297