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STK17B Antibody

  • 货号：
    CSB-PA022838LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Mouse brain tissue
      All lanes: STK17B antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
    • IHC image of CSB-PA022838LA01HU diluted at 1:300 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STK17B Polyclonal antibody
  • Uniprot No.：
    O94768
  • 基因名：
    STK17B
  • 别名：
    DAP kinase related apoptosis inducing protein antibody; DAP kinase related apoptosis inducing protein kinase 2 antibody; DAP kinase-related apoptosis-inducing protein kinase 2 antibody; Death associated protein kinase related 2 antibody; DRAK 2 antibody; DRAK2 antibody; Serine/threonine kinase 17b antibody; Serine/threonine kinase 17b apoptosis inducing antibody; Serine/threonine protein kinase 17B antibody; Serine/threonine-protein kinase 17B antibody; ST17B_HUMAN antibody; STK 17B antibody; Stk17b antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase 17B protein (235-366AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STK17B Antibody (CSB-PA022838LA01HU)，的标记方式是Non-conjugated。对于STK17B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022838LB01HU STK17B Antibody, HRP conjugated ELISA
    FITC CSB-PA022838LC01HU STK17B Antibody, FITC conjugated
    Biotin CSB-PA022838LD01HU STK17B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis.
  • 基因功能参考文献：
    1. ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site. PMID: 23398943
    2. DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells. PMID: 23122956
    3. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation. PMID: 21148796
    4. DRAK2 kinase activity is regulated in a calcium-dependent manner and that Ser(12) phosphorylation is necessary for optimal suppression of T cell activation by this kinase PMID: 17182616
    5. Strong suppression of T cell receptor signals during thymic selection caused by ectopic DRAK2 expression in a DRAK2 transgenic mouse model of autoimmune encephalomyelitis alters the responsiveness of peripheral T cells. PMID: 19542440
    6. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. PMID: 19638987

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  • 亚细胞定位：
    Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily
  • 组织特异性：
    Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.
  • 数据库链接：

    HGNC: 11396

    OMIM: 604727

    KEGG: hsa:9262

    STRING: 9606.ENSP00000263955

    UniGene: Hs.88297