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  4. Recombinant Human Regulator of cell cycle RGCC (RGCC)

Recombinant Human Regulator of cell cycle RGCC (RGCC)

  • 中文名称：
    人RGCC重组蛋白
  • 货号：
    CSB-YP863982HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RGCC重组蛋白
  • 货号：
    CSB-EP863982HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RGCC重组蛋白
  • 货号：
    CSB-EP863982HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RGCC重组蛋白
  • 货号：
    CSB-BP863982HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RGCC重组蛋白
  • 货号：
    CSB-MP863982HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RGCC
  • Uniprot No.：
  • 别名：
    RGCC; C13orf15; RGC32; Regulator of cell cycle RGCC; Response gene to complement 32 protein; RGC-32
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-137
  • 氨基酸序列
    MKPPAAQGSP AAAAAAAPAL DSAAAEDLSD ALCEFDAVLA DFASPFHERH FHYEEHLERM KRRSSASVSD SSGFSDSESA DSLYRNSFSF SDEKLNSPTD STPALLSATV TPQKAKLGDT KELEAFIADL DKTLASM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.
  • 基因功能参考文献：
    1. RGC32 facilitates epithelial-mesenchymal transition of colorectal cancer cells by activating Smad/Sip1 signaling. PMID: 28470188
    2. This study demonstrated the up-regulation of RGC-32 contributed to the imbalance of Treg/Th17 cells in patients with Dilated Cardiomyopathy. [RGC-32] PMID: 29035886
    3. RGC-32 mediates human aortic endothelial cell migration through the regulation of RhoA and ROCK1 expression. PMID: 27619159
    4. RGCC may be a candidate cell cycle target for neuroprotection during the onset of Alzheimer's disease. PMID: 27938491
    5. RGC-32 expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4. PMID: 25418473
    6. Data suggest that expression of RGC32 is down-regulated in placental trophoblasts in women with pre-eclampsia as compared to women with normal term pregnancies; silencing RGC32 expression by RNA interference inhibits trophoblast migration/invasion. PMID: 25655049
    7. Suggest that RGC32 is involved in tumorigenesis of human lung cancer, inducing apoptosis and inhibiting cell growth, migration, and invasion. PMID: 24833469
    8. In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene. PMID: 25230890
    9. results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis. PMID: 24973210
    10. RGC32 promotes cell migration and invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-kappaB signaling pathway. PMID: 23715780
    11. data suggest RGC-32 plays a dual role in multiple sclerosis, both as a regulator of T-cells mediated apoptosis and as a promoter of TGF-beta-mediated profibrotic effects in astrocytes PMID: 23000427
    12. analysis of upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells, due to transcriptional activation by high levels of the differentially expressed RUNX1c transcription factor PMID: 22163048
    13. Data demonstrate that RGC-32 interacts with Smad3 to mediate the epithelial-mesenchymal transition of human renal proximal tubular cells. PMID: 21307346
    14. methylation-associated down-regulation of RGC32 plays an important role in the pathogenesis of NSCLC, particularly in females PMID: 20862745
    15. RGC-32 may contribute to the development of colon cancer by regulating chromatin assembly. PMID: 19883641
    16. RGC-32 overexpression might be part of the deregulation of the cell cycle that is required for the growth of tumor cells PMID: 15713436
    17. Endogenous p53 protein binds to the promoter region of the RGC32 gene, implying p53-dependent transcriptional activity. PMID: 17146433
    18. Spacial/temporal-specific expression of Rgc32 in the ovary and expression in granulosa cells. PMID: 18308847
    19. RGC-32 plays a critical role in TGF-beta-induced epithelial-mesenchymal transition of renal tubular cells PMID: 19158077
    20. Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 dependent and this is in part through regulation of Akt and growth factor release. PMID: 19162005
    21. RGC-32 plays an important homeostatic role in that it contributes to differentiating the pathways for vascular endothelial growth factor and fibroblast growth factor 2 in angiogenesis and provides a new target for ischemic disorder and tumor therapies. PMID: 19652095

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
  • 组织特异性：
    Detected in brain, heart and liver (at protein level). Highly expressed in liver, skeletal muscle, kidney and pancreas. Detected at lower levels in heart, brain and placenta. Detected in aorta endothelial cells. Overexpressed in colon, breast, prostate, b
  • 数据库链接：

    HGNC: 20369

    OMIM: 610077

    KEGG: hsa:28984

    STRING: 9606.ENSP00000368664

    UniGene: Hs.507866