Recombinant Human Protein phosphatase 1 regulatory subunit 1B (PPP1R1B)

1. t-Darpp phosphorylation at T39 seems to be crucial for t-Darpp-mediated PKA activation and this activation appears to occur through an association with RI and sequestering of RI away from PKAc. The t-Darpp-RI interaction could be a druggable target to reduce PKA activity in drug-resistant cancer. PMID: 28867659
2. our results lend support for a potential role of DARPP-32 genetic variants in neural response to potential reward triggering cues PMID: 29048604
3. To facilitate live-cell identification, a human embryonic stem cell line was generated using CRISPR-mediated gene editing at the DARPP32 locus. PMID: 28065797
4. Study associates polymorphisms in DRD2, DARPP-32, and COMT genes with novel category learning performance. Modeling results suggest that striatal dopaminergic genes influence selective attention processes whereas cortical genes mediate the ability to update complex rule representations. PMID: 26918585
5. Results show that expression of human DARPP-32 protein isoforms depends on the striatal neurodevelopmental stage with t-DARPP being specific for the human adult striatum. PMID: 27475250
6. In vivo xenograft models demonstrated that overexpression of DARPP-32 promotes angiogenesis and tumour growth. PMID: 25779598
7. This study strongly suggests that inflammation-regulated DARPP-32 constitutes a key component of H. pylori-mediated gastric tumourigenesis. PMID: 27590997
8. This study did not find any statistical difference in the state-anxiety dimension for the rs12601930C/T, rs879606A/G, and rs3764352A/G genotypes, but statistical differences in the trait-anxiety dimension for the rs879606A/G (F = 5.207, P = 0.006) and rs3764352A/G (F = 3.960, P = 0.020) genotype. PMID: 27995567
9. DARPP-32 is mainly cleaved at Thr(153) by calpain and this cleavage of DARPP-32 reduces CREB phosphorylation via loss of its inhibitory function on PP1; results suggest a novel mechanism of DARPP-32-CREB signalling dysregulation in Alzheimer's disease PMID: 26178297
10. No significant differences in mRNA expression levels of DRD2 and DARPP-32 were found among controls, patients with psychotic disorder not otherwise specified, and schizophrenia/schizophreniform disorder. PMID: 26561806
11. Striatal function was indexed by a gene coding for DARPP-32, which is densely expressed in the striatum where it is necessary for synaptic plasticity PMID: 26818509
12. Findings show that PPP1R1B-STARD3 fusion transcript has a key role in subsets of gastric cancers through the activation of PI3K/AKT signaling. PMID: 24276243
13. The results of this study found that the mean t-DARPP expression level in the caudate was higher in patients with schizophrenia than in control individuals. PMID: 24704945
14. Results suggest that variation in PPP1R1B affects the abundance of the splice variant t-DARPP-32 mRNA and may reflect potential molecular mechanisms implicated in schizophrenia and affective disorders PMID: 23295814
15. The immunostaining was more decreased for DARPP-32 than for the morphological changes of striatal neurons in multiple system atrophy. PMID: 23715974
16. This study showed that variations in genotypes relevant for DARPP-32 functions are associated more with aging-related impairments in the explicit than the implicit component of sequence learning. PMID: 24035787
17. density of DARPP-32-immunoreactive (IR) neurons in the II and III layers of the RAIC was significantly decreased (p<0.05) in the schizophrenia group compared with the healthy control group. PMID: 21821092
18. Bcl-2 and DARPP-32 have roles in regulating inositol 1,4,5-trisphosphate receptor phosphorylation and promoting cell survival PMID: 24395794
19. High DARPP32/STAT3, DARPP32/STAT5B, and STAT5B/STAT3 ratios were associated with longer patient progression free survival. PMID: 23250732
20. The present study provides novel evidence for an association between the DARPP-32 gene (SNP rs907094) and attentional control of auditory perception. PMID: 23639477
21. Findings show a novel mechanism by which DARPP-32 promotes cell invasion by regulating CXCR4-mediated activation of the MT1-MMP/MMP-2 pathway. PMID: 23160836
22. PPP1R1B rs12601930 was associated with projection and splitting. rs3764352 was associated with splitting. No significant association was found between rs879606 and defenses. PPP1R1B polymorphisms are involved in immature defenses. PMID: 23080070
23. Our findings support a role for the DRD2 and PPP1R1B genes in conferring risk for autism in families with only affected males and show an additive effect of these genes towards prediction of affected status in our families. PMID: 22559203
24. Our findings uncover a novel mechanism of TRAIL resistance mediated by DARPP-32, whereby it inhibits the intrinsic apoptosis pathway through upregulation of BCL-xL PMID: 22589394
25. DARPP32 has a role in pluripotent stem cell differentiation toward medium-sized spiny neurons PMID: 23250204
26. no significant association of BDNF or DARPP-32 polymorphisms with schizophrenia in Malays. PMID: 22576830
27. the decrease in DARPP-32 in schizophrenia was more marked in neurons of dorsolateral prefrontal cortex than in other cells or other brain regions PMID: 22179181
28. DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. PMID: 21741919
29. [review] Genetic polymorphisms modulating DARPP-32 mRNA expression and cognition in humans are associated with changes in activation in the entire striatum, and striatal connectivity with frontal cortex, without connection to any other brain region. PMID: 20631684
30. the DARPP-32-related pathogenesis in schizophrenia may be more severe in the superior temporal gyrus than previously found in the prefrontal cortex PMID: 21453742
31. Results suggest that polymorphisms in the DARPP-32 gene are involved in the biological mechanisms that confer the traits of novelty seeking and harm avoidance. PMID: 21369787
32. Findings demonstrate that t-DARPP regulates beta-catenin/TCF activity, thereby implicating a novel oncogenic signaling in upper gastrointestinal cancers. PMID: 21447180
33. our data suggest: (i) C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder PMID: 20874815
34. Findings underscore the potential role of t-DARPP in regulating cell growth and proliferation through PI3 kinase-dependent mechanism. PMID: 20836878
35. This study did not find DAOA significant associations with schizophrenia. Thus, PPP1R1B genes do not fit the antagonistic pleiotropy PMID: 20483474
36. The composite expression score, calculated from immunostaining patterns, increased significantly from normal or gastritis to metaplasia, dysplasia, and adenocarcinoma (P < .001). PMID: 20580047
37. DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing. PMID: 20074680
38. t-Darpp and DARPP-32 expression are novel prognostic and predictive biomarkers in breast cancer. PMID: 19301121
39. DARPP 32 frequently are overexpressed in common subtypes of human adenocarcinomas suggest that these proteins may be important in tumorigenesis. PMID: 14508844
40. overexpression of DARPP-32 is associated with gastric cancer PMID: 14991576
41. DARPP-32 expression arises after a phase of dysplasia esophageal squamous cell carcinoma; tumours expressing DARPP-32 progress less rapidly than DARPP-32-negative tumours PMID: 15188007
42. multiple domains in I-1 target cellular PP1 complexes, and I-1 has a role as a cellular regulator of eIF2alpha phosphorylation PMID: 15345721
43. Expression of Darpp-32 is associated with a potent antiapoptotic advantage for cancer cells through a p53-independent mechanism that involves preservation of mitochondrial potential and increased Bcl2 levels. PMID: 16061638
44. Thus, DARPP-32 signaling downstream of DDR1 is a potential new target for effective anti-metastatic breast cancer therapy PMID: 17027969
45. Potential involvement of PPP1R1B in the etiology of nicotine dependence. PMID: 17171661
46. DARPP-32 plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia. PMID: 17290303
47. The up-regulation of ZNRD1 significantly inhibited the drug sensitivity of gastric cancer cells over-expressing DARPP-32, indicating that ZNRD1 may be important in the DARPP-32-mediated MDR of gastric cancer PMID: 17492506
48. The present study suggests that DARPP-32 decreases in the DLPFC of patients with schizophrenia and bipolar disorder. PMID: 17521792
49. The results of this study do not preclude the possibility that the PPP1R1B is a susceptibility gene for schizophrenia in the Chinese population. PMID: 17618027
50. The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions. PMID: 17695523

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HGNC: 9287

OMIM: 604399

KEGG: hsa:84152

STRING: 9606.ENSP00000254079

UniGene: Hs.286192