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  4. Recombinant Human Protein FAM132A (C1QTNF12)

Recombinant Human Protein FAM132A (C1QTNF12)

  • 货号：
    CSB-YP713130HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713130HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713130HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713130HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C1QTNF12
  • Uniprot No.：
  • 别名：
    C1QTNF12; C1QDC2; CTRP12; FAM132AAdipolin; Adipose-derived insulin-sensitizing factor; C1q and TNF related protein 12; Complement C1q tumor necrosis factor-related protein 12) [Cleaved into: Adipolin fC1QTNF12; Adipolin fCTRP12; Adipolin full-length form); Adipolin gC1QTNF12; Adipolin cleaved form; Adipolin gCTRP12)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-302
  • 氨基酸序列
    GGVGARREAQ RTQQPGQRAD PPNATASASS REGLPEAPKP SQASGPEFSD AHMTWLNFVR RPDDGALRKR CGSRDKKPRD LFGPPGPPGA EVTAETLLHE FQELLKEATE RRFSGLLDPL LPQGAGLRLV GEAFHCRLQG PRRVDKRTLV ELHGFQAPAA QGAFLRGSGL SLASGRFTAP VSGIFQFSAS LHVDHSELQG KARLRARDVV CVLICIESLC QRHTCLEAVS GLESNSRVFT LQVQGLLQLQ AGQYASVFVD NGSGAVLTIQ AGSSFSGLLL GT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
  • 基因功能参考文献：
    1. Adipolin and adiponectin are cytokines that exert substantial impact on obesity, progression of atherosclerosis, insulin resistance, and glucose metabolism. PMID: 29452073
    2. Low serum CTRP12 level is associated with Type 2 diabetes mellitus. PMID: 28207876
    3. Coenzyme Q10 reduced HbA1c considerably in overweight and obese patients with diabetes, although interestingly adipolin levels declined simultaneously. In this study, Q10 modulated glucose homeostasis, which was expected to be mediated by increasing adipolin. The similar mechanisms of action of Q10 and adipolin may justify lowering effect of Q10 on adipolin. PMID: 27657997
    4. Serum adipolin concentrations were significantly lower in polycystic ovarian syndrome compared with control subjects. PMID: 24612181
    5. In subcutaneous adipose tissue explants, insulin significantly increased CTRP12 protein expression and secretion. PMID: 24492466
    6. we describe, for the first time, adipolin expression in human chondrocytes as well as the intracellular mechanism involved in its regulation PMID: 22736092
    7. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. PMID: 22942287
    8. Reports cloning, expression, regulation and function of mouse adipolin (Fam132a) PMID: 21849507

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  • 亚细胞定位：
    [Adipolin fC1QTNF12]: Secreted.; [Adipolin gC1QTNF12]: Secreted.
  • 蛋白家族：
    Adipolin/erythroferrone family
  • 组织特异性：
    Predominantly expressed by adipose tissues.
  • 数据库链接：

    HGNC: 32308

    OMIM: 616593

    KEGG: hsa:388581

    STRING: 9606.ENSP00000329137

    UniGene: Hs.197613