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  4. Recombinant Human Probable ATP-dependent RNA helicase YTHDC2 (YTHDC2)

Recombinant Human Probable ATP-dependent RNA helicase YTHDC2 (YTHDC2)

  • 中文名称：
    人YTHDC2重组蛋白
  • 货号：
    CSB-YP867160HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人YTHDC2重组蛋白
  • 货号：
    CSB-EP867160HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人YTHDC2重组蛋白
  • 货号：
    CSB-EP867160HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人YTHDC2重组蛋白
  • 货号：
    CSB-BP867160HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人YTHDC2重组蛋白
  • 货号：
    CSB-MP867160HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YTHDC2
  • Uniprot No.：
  • 别名：
    YTHDC2; 3'-5' RNA helicase YTHDC2; EC 3.6.4.13; YTH domain-containing protein 2; hYTHDC2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
  • 基因功能参考文献：
    1. YTHDC2 was recently found to promote a "fast-track" expression program for specific mRNAs, and our data suggest that YTHDC2 accomplishes this by recruitment of the RNA degradation machinery to regulate the stability of m(6)A-containing mRNAs and by utilizing its distinct RNA-binding domains to bridge interactions between m(6)A-containing mRNAs and the ribosomes to facilitate their efficient translation. PMID: 29970596
    2. Suggest that RNA helicase YTHDC2 contributes to colon adenocarcinoma metastasis by promoting translation of HIF-1alpha. PMID: 26996300
    3. Our results suggest that the YTHDC2 gene could be a potential candidate for pancreatic cancer susceptibility and a useful marker for early detection PMID: 24834797
    4. data show that YTHDC2 plays an important role in tumor cells growth and activation/recruitment of c-Jun and ATF-2 to the YTHDC2 promoter is necessary for the transcription of YTHDC2 PMID: 24269672
    5. CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV. PMID: 21559518

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 组织特异性：
    Expressed in testis. Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis.
  • 数据库链接：

    HGNC: 24721

    OMIM: 616530

    KEGG: hsa:64848

    STRING: 9606.ENSP00000161863

    UniGene: Hs.231942