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  4. Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 (PIK3R6)

Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 (PIK3R6)

  • 货号：
    CSB-YP719469HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP719469HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP719469HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP719469HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP719469HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C17orf38; Chromosome 17 open reading frame 38; HsT41028; p84 PI3K adapter protein; p84 PIKAP; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein; p87 PI3K adapter protein; p87PIKAP; Phosphatidylinositol 3-kinase; regulatory subunit 6; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; Phosphoinositide 3-kinase regulatory subunit 6; PI3Kgamma adapter protein of 87 kDa; PI3R6_HUMAN; PIK3R6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-754
  • 氨基酸序列
    MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS PVLVRILLRE LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA FCTRLLTLPT PYCTVALDCA IRLKTEMAVP GTLYQRMVIA EQNLTNELYP YQERVFLFVD PELVSASVCS ALLLEIEAAQ AQQTPETCMR HVVSHALQAA LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA SPSREGHVER LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA DELPAPGSPE MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP SGDGEMLPGV SRLHTARVLV LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR LSLQLYYIPV LAPEKPAASR QPELGELATF LGRVDPWYQS NVNTLCPAIH KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT VKIFFSDLSQ DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV TEVVKSSNLA GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD VVRFEVAPCP EPCSGAQKSK APWLNLHGQQ EVEAIKAKPK PLLMPINTFS GIVQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
  • 基因功能参考文献：
    1. Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. PMID: 25753393
    2. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
    3. knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization PMID: 21996737
    4. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] PMID: 16476736
    5. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells PMID: 18323525
    6. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma PMID: 18596232

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 数据库链接：

    HGNC: 27101

    OMIM: 611462

    KEGG: hsa:146850

    UniGene: Hs.255809