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  4. Recombinant Human Organic solute transporter subunit beta (OSTB), partial

Recombinant Human Organic solute transporter subunit beta (OSTB), partial

  • 货号：
    CSB-YP771440HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP771440HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP771440HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP771440HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP771440HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC51B
  • Uniprot No.：
  • 别名：
    SLC51B; OSTB; Organic solute transporter subunit beta; OST-beta; Solute carrier family 51 subunit beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
  • 基因功能参考文献：
    1. Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting. PMID: 27351185
    2. Hepatic OSTalpha-OSTbeta expression is induced by hypoxia. PMID: 24703425
    3. OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways PMID: 24264050
    4. Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes. PMID: 22535958
    5. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues. PMID: 21691099
    6. OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis PMID: 20649839
    7. OSTbeta has roles in biological transport and is widely expressed in human tissues PMID: 12719432
    8. overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes PMID: 16251721
    9. OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR). PMID: 16269519
    10. the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. PMID: 16317684
    11. These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. PMID: 16423920
    12. Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity. PMID: 17332473
    13. The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers PMID: 18469300
    14. interaction of solute transporter beta with human organic solute transporter alpha. PMID: 18847488

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  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
  • 蛋白家族：
    OST-beta family
  • 组织特异性：
    Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
  • 数据库链接：

    HGNC: 29956

    OMIM: 612085

    KEGG: hsa:123264

    STRING: 9606.ENSP00000335292

    UniGene: Hs.27018