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SLC51B Antibody

  • 货号：
    CSB-PA771440LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of HepG2 cells using CSB-PA771440LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC51B Polyclonal antibody
  • Uniprot No.：
    Q86UW2
  • 基因名：
    SLC51B
  • 别名：
    SLC51B antibody; OSTB antibody; Organic solute transporter subunit beta antibody; OST-beta antibody; Solute carrier family 51 subunit beta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Organic solute transporter subunit beta protein (57-128AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC51B Antibody (CSB-PA771440LA01HU)，的标记方式是Non-conjugated。对于SLC51B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA771440LB01HU SLC51B Antibody, HRP conjugated ELISA
    FITC CSB-PA771440LC01HU SLC51B Antibody, FITC conjugated
    Biotin CSB-PA771440LD01HU SLC51B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
  • 基因功能参考文献：
    1. Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting. PMID: 27351185
    2. Hepatic OSTalpha-OSTbeta expression is induced by hypoxia. PMID: 24703425
    3. OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways PMID: 24264050
    4. Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes. PMID: 22535958
    5. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues. PMID: 21691099
    6. OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis PMID: 20649839
    7. OSTbeta has roles in biological transport and is widely expressed in human tissues PMID: 12719432
    8. overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes PMID: 16251721
    9. OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR). PMID: 16269519
    10. the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. PMID: 16317684
    11. These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. PMID: 16423920
    12. Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity. PMID: 17332473
    13. The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers PMID: 18469300
    14. interaction of solute transporter beta with human organic solute transporter alpha. PMID: 18847488

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  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
  • 蛋白家族：
    OST-beta family
  • 组织特异性：
    Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
  • 数据库链接：

    HGNC: 29956

    OMIM: 612085

    KEGG: hsa:123264

    STRING: 9606.ENSP00000335292

    UniGene: Hs.27018