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  4. Recombinant Human Oligodendrocyte transcription factor 2 (OLIG2)

Recombinant Human Oligodendrocyte transcription factor 2 (OLIG2)

  • 货号：
    CSB-EP623814HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    OLIG2
  • Uniprot No.：
  • 别名：
    Basic domain helix loop helix protein class B 1; Basic helix loop helix protein class B 1; BHLHB; bHLHB1; bHLHe19; Class B basic helix loop helix protein 1; Class B basic helix-loop-helix protein 1; class E basic helix loop helix protein 19; Class E basic helix-loop-helix protein 19; Human protein kinase C binding protein RACK17; Olig2; OLIG2_HUMAN; Oligo2; Oligodendrocyte lineage transcription factor 2; Oligodendrocyte specific bHLH transcription factor 2; Oligodendrocyte transcription factor 2; OTTHUMP00000067569; OTTHUMP00000067570; PRKCBP2; Protein kinase C binding protein 2; Protein kinase C binding protein RACK17; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17; RACK17
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    48.4kDa
  • 表达区域：
    1-323aa
  • 氨基酸序列
    MDSDASLVSSRPSSPEPDDLFLPARSKGSSGSAFTGGTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKLGGSGFKSSSSSTSSSTSSAAASSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGSLPRLTSDAK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • 基因功能参考文献：
    1. indicate Olig2 as an onco-requisite factor in diffuse intrinsic pontine glioma PMID: 28339768
    2. OLIG2 immunoreactivity was observed in GABAergic cells of the proliferative zones of the MGE and septum, but not necessarily co-expressed with NKX2.1, and OLIG2 expression was also extensively seen in the LGE, CGE, and cortex PMID: 27905023
    3. Data suggest positive feedback loops including oligodendrocyte transcription factor 2 (OLIG2): loops of epigenetic regulation. PMID: 27447975
    4. Data show that oligodendrocyte transcription factor 2 (OLIG2) is epigenetically regulated via DNA methylation and expressed in a subset of AML patients. PMID: 28760688
    5. Ectopic expression of phosphomimetic Olig2 is sufficient to block TGF-beta2-mediated invasion. PMID: 27396340
    6. phosphorylation of the motif itself serves as a template to prime phosphorylation of additional serines and creates a highly charged "acid blob" in the amino terminus of Olig2. PMID: 28355568
    7. Olig2 was expressed in cord blood eosinophils on d 24, when cord blood eosinophils are considered fully differentiated, but no earlier. It was also expressed in human peripheral-blood eosinophils but not neutrophils, monocytes, lymphocytes, or cord blood mast cells. Many genes, including eosinophil surface molecules, were up-regulated along with OLIG2. OLIG2 shRNA or siRNA downregulated SIGLEC-8 mRNA and protein. PMID: 27154355
    8. Data indicate that transcription factors Sox10 and Olig2 play key roles in oligodendrocytes (OLs) specification. PMID: 27785726
    9. Olig2 expressions were successfully detected in 12 (15.58%) of 77 SVZ type II Glioblastomas (GBs) and 16 (21.3%) of 75 SVZ type III GBs. PMID: 27179219
    10. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors PMID: 26287936
    11. The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population. Thus, OLIG2 might serve as a potential target for OCD treatment PMID: 26271930
    12. The results demonstrate that the expression of Olig2 in dental pulp stem cells reduces the expression of stem cell markers and induces the development of oligodendrocyte progenitors. PMID: 25966902
    13. High Olig2 expression is associated with oligodendrogliomas. PMID: 25085214
    14. OLIG2 is the most specific GSC marker. PMID: 25384509
    15. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. PMID: 24821492
    16. s investigated the role of Pten in these two critical cellular compartments in adult and developing brains using methods for activation or suppression of PI3K signaling in glial and neuronal progenitors expressing Olig2. PMID: 24395742
    17. LGR5 expression may be functionally correlated with the neurogenic competence, and be regulated by OLIG2 in stem-like cells in glioblastoma. PMID: 23793848
    18. We found that the risk allele OLIG2 (A) was associated with reduced white matter integrity in the corona radiata bilaterally PMID: 22505278
    19. Olig2-positive cells in glioneuronal tumors, and some of them also exhibited neuronal features PMID: 23025580
    20. Report role of OLIG2 immunostaining pattern in diagnosing rare and glioblastoma variants. PMID: 23041832
    21. This study review OLIG2 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
    22. OLIG2 over-expression inhibits neural progenitor proliferation through changes in potassium channel activity, thereby contributing to the reduced neuronal numbers and brain size in DS. PMID: 22343408
    23. Nogo-A is more useful and specific than Olig-2 in differentiating oligodendrogliomas from other gliomas. PMID: 21835431
    24. Olig2 expression is restricted to isolation and during membrane production of regenerating oligodendrocyte cultures isolated from white matter of medically intractable epilepsy patients. PMID: 21446039
    25. The Olig2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    26. suggesting that OLIG2 function in pediatric gliomas is cell lineage dependent PMID: 21193945
    27. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    28. 1p19q whole loss was also significantly associated with Olig2 overexpression, but was never observed in tumors overexpressing p53 protein in oligodendroglial tumors PMID: 20081802
    29. Analysis of 180 primary, metastatic, and non-neural human tumors shows OLIG2 is highly expressed in all diffuse gliomas. Immunohistochemistry and microarray analyses demonstrate higher OLIG2 in anaplastic oligodendrogliomas versus glioblastomas. PMID: 15198128
    30. Overexpression of OLIG2 was not only found in oligodendroglioma samples and normal neural tissue but also in a wide spectrum of malignant cell lines including leukemia, non-small cell lung carcinoma, melanoma, and breast cancer cell lines. PMID: 16103065
    31. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
    32. Transcriptional regulation of transgenic Olig2 is involved in segregation of motoneuron precursor neuroblasts in the developing mouse spinal cord. PMID: 16469306
    33. A novel function of OLIG2 is to suppress glial tumor cell growth via cyclin-dependent kinase inhibitor p27. PMID: 16554441
    34. Findings show a general requirement for Olig2 function in glial cell development and highlight further roles for Olig transcription factors in neural progenitor cells. PMID: 16682644
    35. Data provide strong convergent evidence that variation in OLIG2 confers susceptibility to schizophrenia alone and as part of a network of genes implicated in oligodendrocyte function. PMID: 16891421
    36. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
    37. OLIG2 expression was predominant over ID2 expression in oligodendroglial tumors, while ID2 expression was predominant over OLIG2 expression in astrocytic tumors. PMID: 17431671
    38. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-2 expression. PMID: 17690840
    39. IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas PMID: 17917751
    40. absence of OLIG2 mutation in three PMLD patients presenting with a phenotype characterized by severe hypomyelination and motor neuron dysfunction PMID: 17918228
    41. The SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population. PMID: 17934761
    42. OLIG2 suppresses the motile phenotype of glioblastoma cells by activating RhoA. PMID: 17951409
    43. We found that genetic polymorphisms in CNP (rs2070106) and OLIG2 (rs1059004 and PMID: 17964117
    44. analysis of Olig2 immunohistochemistry in microcystic areas might therefore be useful for the differential diagnosis of pilocytic astrocytoma and diffuse astrocytomas . PMID: 18312545
    45. Olig2-immunohistochemistry is useful and potentially more reliable than the epithelial membrane antigen-immunohistochemistry for the diagnosis of ependymoma PMID: 18552083
    46. Olig2-induced neural stem cell differentiation involves downregulation of Wnt pathway. PMID: 19093005
    47. Significant evidence for association of psychotic symptoms within cases was identified for two SNPs, rs762237 and rs2834072. PMID: 19477230
    48. transplantation of human neural stem cells genetically modified to express Olig2 transcription factor improved locomotor recovery and enhanced myelination in a rat contusive spinal cord injury model. PMID: 19772605

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  • 相关疾病：
    A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • 数据库链接：

    HGNC: 9398

    OMIM: 606386

    KEGG: hsa:10215

    STRING: 9606.ENSP00000331040

    UniGene: Hs.176977