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  4. Recombinant Human Nuclear receptor 2C2-associated protein (NR2C2AP)

Recombinant Human Nuclear receptor 2C2-associated protein (NR2C2AP)

  • 货号：
    CSB-YP016053HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016053HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016053HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016053HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016053HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NR2C2AP
  • Uniprot No.：
  • 别名：
    nr2c2ap; NR2CA_HUMAN; Nuclear receptor 2C2 associated protein; Nuclear receptor 2C2-associated protein; Repressor for TR4 transactivation ; TR4 orphan receptor associated 16 kDa protein; TR4 orphan receptor associated protein TRA16 ; TR4 orphan receptor-associated 16 kDa protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-139
  • 氨基酸序列
    MTHSLVCPET VSRVSSVLNR NTRQFGKKHL FDQDEETCWN SDQGPSQWVT LEFPQLIRVS QLQIQFQGGF SSRRGCLEGS QGTQALHKIV DFYPEDNNSL QTFPIPAAEV DRLKVTFEDA TDFFGRVVIY HLRVLGEKV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.
  • 基因功能参考文献：
    1. High TRA16 expression promotes small cell lung carcinoma by activating estrogen receptor beta and blocking testicular orphan nuclear receptor 2 PMID: 23129017
    2. TRA16 may function as a novel repressor to selectively suppress the TR4-mediated transactivation PMID: 12486131
    3. Together, these findings provide the first in vivo evidence that an orphan nuclear receptor, such as TR4, may play major roles in the RA-mediated apoptosis or differentiation in P19 cells. PMID: 15381082
    4. Taken together, these results suggested that TR4 should be one of important regulators of OXT gene expression. PMID: 17054912
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NR2C2AP family
  • 组织特异性：
    Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 30763

    OMIM: 608719

    KEGG: hsa:126382

    STRING: 9606.ENSP00000332823

    UniGene: Hs.708153