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  4. Recombinant Human Neuronal growth regulator 1 (NEGR1)

Recombinant Human Neuronal growth regulator 1 (NEGR1)

  • 货号：
    CSB-YP015692HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015692HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015692HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015692HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015692HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NEGR1
  • Uniprot No.：
  • 别名：
    NEGR1; IGLON4; UNQ2433/PRO4993; Neuronal growth regulator 1; IgLON family member 4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    38-324
  • 氨基酸序列
    VDF PWAAVDNMMV RKGDTAVLRC YLEDGASKGA WLNRSSIIFA GGDKWSVDPR VSISTLNKRD YSLQIQNVDV TDDGPYTCSV QTQHTPRTMQ VHLTVQVPPK IYDISNDMTV NEGTNVTLTC LATGKPEPSI SWRHISPSAK PFENGQYLDI YGITRDQAGE YECSAENDVS FPDVRKVKVV VNFAPTIQEI KSGTVTPGRS GLIRCEGAGV PPPAFEWYKG EKKLFNGQQG IIIQNFSTRS ILTVTNVTQE HFGNYTCVAA NKLGTTNASL PLNPPSTAQY GITG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain.
  • 基因功能参考文献：
    1. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. PMID: 28428959
    2. NEGR1, strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings. PMID: 28969442
    3. Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder. PMID: 27479909
    4. Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes PMID: 27005443
    5. NEGR1 interacts with NPC2 and increases its protein stability; it has a role in obesity PMID: 27940359
    6. Genetic variants associated with BMI and WHR in adults influence growth patterns and general and abdominal fat development from early childhood onwards. PMID: 25640768
    7. We observed novel selection signals in CDKAL1 and NEGR1, well-known diabetes and obesity susceptibility genes PMID: 25370040
    8. NEGR1 could be an important locus influencing certain personality dimensions in BN patients. PMID: 25245582
    9. First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity. PMID: 25072390
    10. Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO gene and SNP rs2815752 near the NEGR1 gene. PMID: 23950990
    11. Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
    12. Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2. PMID: 22443470
    13. Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 PMID: 21750520
    14. Gene-treatment interactions were observed for long-term (NEGR1 rs2815752, Pmetformin*SNP = 0.028; FTO rs9939609, Plifestyle*SNP = 0.044) weight loss. PMID: 22179955
    15. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    16. Data suggest that in addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network. PMID: 21427694
    17. The results of these studies provide supporting evidence for MYEOV and NEGR1 as gene targets of 11q13 gains and 1p31 deletions in a neuroblastoma subset. PMID: 21624008
    18. Observational study of gene-disease association. (HuGE Navigator) PMID: 20712903
    19. Observational study of gene-disease association. (HuGE Navigator) PMID: 20724581
    20. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20725061
    21. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816152
    22. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
    23. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20571754
    24. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 20816195
    26. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    27. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20386550
    28. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20520848
    29. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20215397
    30. Observational study of gene-disease association. (HuGE Navigator) PMID: 19746409
    31. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19812171
    32. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851340
    33. Observational study of gene-disease association. (HuGE Navigator) PMID: 19910938
    34. Observational study of gene-disease association. (HuGE Navigator) PMID: 19692490
    35. Observational study of gene-disease association. (HuGE Navigator) PMID: 19164386
    36. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19079261

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, IgLON family
  • 数据库链接：

    HGNC: 17302

    OMIM: 613173

    KEGG: hsa:257194

    STRING: 9606.ENSP00000350364

    UniGene: Hs.146542