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  4. Recombinant Human N-formyl peptide receptor 2 (FPR2), partial

Recombinant Human N-formyl peptide receptor 2 (FPR2), partial

  • 货号：
    CSB-YP008855HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008855HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008855HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008855HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008855HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FPR2; FPRH1; FPRL1; LXA4R; N-formyl peptide receptor 2; FMLP-related receptor I; FMLP-R-I; Formyl peptide receptor-like 1; HM63; Lipoxin A4 receptor; LXA4 receptor; RFP
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin.
  • 基因功能参考文献：
    1. FPR2 promotes invasion and metastasis of gastric cancer cells and predicts the prognosis of patients. PMID: 28600569
    2. Phenol-soluble modulin (PSM) peptides from highly pathogenic Staphylococcus aureus are efficient ligands for FPR2. PMID: 28855276
    3. these results show that FPR2signaling interferes with the endosomal trafficking of influenza viruses and provides, for the first time, the proof of concept that monoclonal antibodies directed against FPR2 inhibit virus replication PMID: 29738458
    4. serum amyloid A (SAA) may stimulate the migration of SKOV3 cells through FPR2. The present study suggested that FPR2 promoted the invasion and metastasis of Epithelial ovarian cancer (EOC) and it could be a prognostic marker for EOC. PMID: 29039544
    5. plasma levels higher in preeclamptic women than in nonpregnant and normotensive pregnant women, and similar between nonpregnant and normotensive pregnant women PMID: 27179254
    6. Our findings provide evidence for defective LXA4 generation and FPR2/ALXR expression that, associated with increased LTB4, might be involved in a reduction in the ability of inhaled corticosteroids to impair control of airway inflammation in children with SA. PMID: 26971688
    7. These data show that viral replication and IAV pathogenesis depend on FPR2 signaling and suggest that FPR2 may be a promising novel strategy to treat influenza. PMID: 27034344
    8. Changes in the histone acetylation/methylation status enhanced FPR2 signaling in response to LXA4 during inflammation process. PMID: 27424221
    9. a novel FPR2 agonist, the proteolytically stable alpha-peptide/beta-peptoid hybrid Lau-((S)-Aoc)-(Lys-betaNphe)6-NH2 (F2M2), showing comparable potency in activating human and mouse neutrophils by inducing a rise in intracellular Ca(2+) concentration and assembly of the superoxide-generating NADPH oxidase. PMID: 27422818
    10. We conclude that ANX-A1 is an important regulator of mast cell reactivity to compound 48/80 exerting a negative feedback effect through a mechanism that depends at least partly on the FPR receptor PMID: 26803520
    11. pro-inflammatory stimuli lead to FPR2/ALX expression while LXA4 induces an anti-inflammatory response PMID: 26248046
    12. Data show that the purinergic receptor P2Y2 (P2Y2R) pepducin activates neutrophils through formyl peptide receptor 2 (FPR2), and ATP is turned into an activating agonist through a receptor cross-talk mechanism that involves both FPR2 and P2Y2R. PMID: 26996596
    13. Lipoxin A4 may have a role in preventing metabolic syndrome in a middle-aged Chinese population PMID: 26565966
    14. Serum amyloid A1alpha induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils. PMID: 26297794
    15. significant increase in expression of mRNA in placenta from women with pre-eclampsia PMID: 24960456
    16. ANXA1 may contribute to the regulation of tumor growth and metastasis through paracrine mechanisms that are mediated by FPR2/ALX PMID: 25490767
    17. Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis PMID: 25304660
    18. Expression of FPR2/ALX was analysed in 127 carotid atherosclerotic lesions and revealed that this receptor was expressed on macrophages, smooth muscle cells, and endothelial cells. PMID: 25341894
    19. There was an excessive maternal inflammatory response in preeclampsia. LXA4, ALX-R, and NF-kappaB p65 may be involved in the disease process ofpreeclampsia. PMID: 25864260
    20. Molecular determinants required for modulation of endocytic recycling in the anti-apoptotic function of FPR2/ALX. PMID: 25326384
    21. A stable peptidomimetic inhibited the activation of human neutrophils via direct interaction with FPR2. PMID: 25462815
    22. The effects of diclofenac on the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography via lipoxin A4 and resolvin D1 and E1 levels is reported. PMID: 25030943
    23. Uteroglobin is a possible ligand of the lipoxin receptor and it may have a role in inhibiting serum amyloid A-driven inflammation PMID: 24782597
    24. The MAT-1 can induce chemotaxis specifically using FPR2, a receptor found on the surface of monocytes, macrophages and neutrophils. PMID: 24617769
    25. We also found that human mast cells expressed the N-formyl-peptide receptor 1 (FPRL1) receptor and FPRL1-specific inhibitor affected pleurocidin-mediated activation of mast cell. PMID: 23839065
    26. LXA decreased IgM and IgG production on activated human B cells through ALX/FPR2-dependent signaling. PMID: 24166736
    27. Structural determinants for the interaction of formyl peptide receptor 2 with peptide ligands. PMID: 24285541
    28. The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling. PMID: 24067461
    29. FPR2 is expressed in minor salivary glands with and without Sjogren's syndrome. PMID: 24259417
    30. lipoxin A4 may play a role in the resolution of upper airway inflammation. A low concentration of lipoxin A4 may be involved in chronic inflammation of the upper airways. PMID: 24358628
    31. Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. PMID: 24108355
    32. FPR2 is not activated by lipoxin (LX)A; the molecular mechanism by which LXA functions still needs to be identified. PMID: 23643932
    33. Cross-talk between FPR2 and HGF receptor in human prostate epithelial cells. PMID: 23583448
    34. FPR2 is upregulated in peripheral blood mononuclear cells from patients with atherosclerosis. PMID: 23500463
    35. FPRL1 is responsible for TLR3 signaling induced by LL-37-poly(I:C). PMID: 23386607
    36. It was concluded that the ability of FPR2 to discriminate between the enantiomers is the consequence of the arrangement of three asymmetric hydrophobic subpockets at the main orthosteric FPR2 binding site. PMID: 23219934
    37. Most of the analyzed Enterococcus faecium but only sporadic Enterococcus faecalis strains released FPR2/ALX-stimulating molecules leading to neutrophil calcium ion fluxes, chemotaxis, and complement receptor upregulation. PMID: 22768166
    38. No evidence for the involvement of the lipoxin A4 receptor (FPR2/ALX ) gene in the susceptibility to coronary artery disease PMID: 22734147
    39. N-terminal region was dispensable for AnxA1-induced FPR2/ALX down-regulation in both the homologous and heterologous desensitization modes. PMID: 22610094
    40. Neutrophil activity induced by a cell-permeable peptide derived from the third intracellular loop of FPR2 is dose-dependently inhibited by membrane-permeable peptide inhibitor PBP10. PMID: 22706076
    41. Single-nucleotide polymorphism located in the intron of FPR2 is related to aspirin hypersensitivity in asthmatics. PMID: 22377711
    42. Results provide information on FPR2/ALX transcriptional regulation and evidence of mutations that affect FPR2/ALX transcription. PMID: 22131270
    43. These data support a model in which FPR2/ALX plays a role in chemotaxis and activation of monocytes; however, they also suggest that its function in resident tissue macrophages is limited. PMID: 22246625
    44. FPR2 has an appreciable pleiotropic regulator role in tumor immunoediting PMID: 21499310
    45. SAA up-regulates PTX3 production via FPRL1 significantly, and thus, contributes to the inflammatory pathogenesis of atherosclerosis. PMID: 21465531
    46. N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation. PMID: 21543323
    47. Data sugget the existence of an endogenous network in anti-inflammation centered on PMN AnxA1 and activated by selective FPR2/ALX agonists. PMID: 21398608
    48. the innate immune system may be able to respond in different ways to pathogenic or innocuous staphylococci by monitoring the presence of phenol-soluble modulins via FPR2. PMID: 21183593
    49. Data suggest that bacteria induce glial cell activation and rCRAMP expression via FPRL1 and MARCO, and these receptors contribute to the host defence against infection. PMID: 21299846
    50. The results indicate that SAA stimulates FPR2-mediated activation of p38 MAPK and JNK, which are independent of a pertussis toxin-sensitive G-protein and are essential for SAA-induced CCL2 production. PMID: 20177146

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Detected in lung, bone marrow, neutrophils, spleen and testis.
  • 数据库链接：

    HGNC: 3827

    OMIM: 136538

    KEGG: hsa:2358

    STRING: 9606.ENSP00000340191

    UniGene: Hs.99855