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  4. Recombinant Human Metastasis-suppressor KiSS-1 (KISS1)

Recombinant Human Metastasis-suppressor KiSS-1 (KISS1)

  • 货号：
    CSB-YP621883HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP621883HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP621883HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP621883HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP621883HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KISS1
  • Uniprot No.：
  • 别名：
    KISS 1; KiSS 1 metastasis suppressor; Kiss1; KISS1_HUMAN; Kisspeptin 1; Kisspeptin 10; Kisspeptin 13; Kisspeptin 14; Kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-54; Kisspeptin1; Malignant melanoma metastasis suppressor; Metastasis suppressor KiSS 1; Metastasis suppressor KiSS1; Metastin; MGC39258
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-138
  • 氨基酸序列
    E PLEKVASVGN SRPTGQQLES LGLLAPGEQS LPCTERKPAA TARLSRRGTS LSPPPESSGS PQQPGLSAPH SRQIPAPQGA VLVQREKDLP NYNWNSFGLR FGKREAAPGN HGRSAGRG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • 基因功能参考文献：
    1. Expression levels of MACC1, CD44, Twist1, and KiSS-1 are related to duration of overall survival among patients with colonic adenocarcinoma. PMID: 30021598
    2. Data suggest KISS1 as a great candidate for Cervical cancer (CC) molecular markers or as a therapeutic target for CC. Also, HPV presence does not seem to alter the KISS1 expression in CC PMID: 29914007
    3. KiSS-1 metastasis-suppressor protein (KISS1) expression promotes secretion of proangiogenic biomarkers and factors modulating anti-cancer immune responses. PMID: 29269086
    4. The genetic variation of KISS1 gene may be a factor contributing to polycystic ovary syndrome development. PMID: 29848339
    5. Kisspeptin and spexin serum levels in women were negatively correlated with obesity and insulin resistance. PMID: 29137471
    6. Data suggest that women with PCOS (polycystic ovary syndrome) exhibit increased serum kisspeptin-1 levels. PMID: 28933574
    7. Our studies revealed that KISS1 inhibits glycolysis and carbon sources for endogenous fatty acid oxidation (FAO). PMID: 28597070
    8. KiSS1 gene is a novel mediator of TGFbeta-mediated cell invasion in triple negative breast cancer. PMID: 28988968
    9. Kisspeptin signaling modulates steroid biosynthesis in Leydig cells. Kisspeptin produced by the interstitium targets spermatogonia and sperm cells to affect spermatogenesis onset/progression and sperm functions, respectively. PMID: 28878091
    10. Kisspeptin inhibited tumor growth through an EIF2AK2dependent mechanism, and an in vivo metastasis assay identified kisspeptinactivated EIF2AK2 signaling as critical for the suppression of distant metastasis. PMID: 28944853
    11. kisspeptin surge in serum and urine may be used as a marker for dominant follicle development and pre-ovulation. PMID: 28266227
    12. High plasma kisspeptin-1 is associated with premature thelarche. PMID: 28422705
    13. expression appears to be up-regulated in adenomyotic as compared with eutopic glandular endometrium of patients with, as well as women without, adenomyosis PMID: 27940396
    14. Data suggest that subjects with anorexia nervosa display broad spectrum of physical activity (2479-26,047 steps/day) which shows a negative correlation with plasma kisspeptin levels and a positive association with plasma ghrelin levels. PMID: 27693487
    15. Kisspeptin-10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 antagonist may be useful for prevention and treatment of atherosclerosis. PMID: 28411243
    16. Kiss-10 levels are significantly altered by malignancy and tumour subtypes even in patients with small renal tumours PMID: 28095383
    17. Study compared kisspeptin-54 and kisspeptin-10 to gain an insight into why KP-54 elicits more sustained responses than KP-10 after systemic delivery PMID: 28464043
    18. we conclude that KISS-1 can inhibit the proliferation of osteosarcoma in vitro by accelerating the processes of apoptosis and autophagy. PMID: 28075440
    19. These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation. PMID: 27046106
    20. Patients with ovarian epithelial cancer and low KISS1 mRNA expression had shorter survival time than those with high expression (P = 0.001).Preoperative KISS1 mRNA was a potential prognostic biomarker for EOC, and high preoperative KISS1 expression indicated a favorable prognosis. PMID: 27861355
    21. Lower expression of KiSS1 was observed in metastatic Breast Cancer. PMID: 27221854
    22. There is an increasing appreciation that kisspeptin may act as a signal transmitter between metabolic status and reproductive function PMID: 26605678
    23. In human cumulus GCs, kiss1r mRNA levels were positively correlated with age but not with BMI. There was no expression of kiss1 mRNA in either cumulus or mural GCs PMID: 26879207
    24. There was a statistically significant increase in serum kisspeptin levels from the early follicular to the preovulatory phase, and from the preovulatory to the luteal phase. PMID: 25968289
    25. Overexpression of KiSS-1 suppressed the invasiveness of CRC cells, and the gene exerted its function by reducing the expression of MMP-9 via blocking of tge PI3K/Akt/NF-kappaB pathway. PMID: 26847533
    26. kisspeptins play essential roles in reproduction [review] PMID: 26702158
    27. Increased placental kisspeptin expression is consistent with reduced trophoblast invasiveness and may represent a molecular mechanism that explains the development of preeclampsia. Decreased circulating kisspeptin concentration has the potential to be utilised as a marker for placental dysfunction. PMID: 26955777
    28. Data suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns. PMID: 26831552
    29. KISS1 Low Expression Correlates with Colorectal Liver Metastasis. PMID: 26471489
    30. KiSS1 is a metastasis suppressor gene of pancreatic cancer, and this suppression is not dependent on the expression levels of GPR54. PMID: 26572251
    31. confirmed that mutations in KISS1 and KISS1R are not a common cause for ICPP PMID: 23950571
    32. KiSS-1 downregulation may play a role in tumor progression and metastasis of oral squamous cell carcinoma, and may be a reliable biomarker for predicting clinical outcome in this disease. PMID: 26809635
    33. These findings are of tremendous significance and will greatly shape how KISS1 will be developed as a therapeutic agent in augmenting the reproductive potential of both women and important livestock species--{REVIEW} PMID: 26183891
    34. On D4 of pregnancy, the Kiss 1 null uterus expresses functional KISS1R molecules. PMID: 26384646
    35. Metastin levels were higher in women with polycystic ovary syndrome as compared to controls regardless of BMI. PMID: 25020276
    36. Metastin expression is induced in ESCs through decidualization. PMID: 24908069
    37. Present data do not confirm the protective role of KiSS1/KiSS1R in breast cancer progression, but our results do support the hypothesis that KiSS1/KiSS1R system is activated even in primary breast cancer and sustained during invasion to local lymph nodes. PMID: 25535062
    38. rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population. PMID: 25810563
    39. The results suggest that mutations in the coding sequence of KISS1 are not common in patients with IHH in this Chinese population. PMID: 25783047
    40. A number of mutations in KISS1 KISS1R are associated with central precocious puberty and isolated hypogonadotropic hypogonadism. (Review) PMID: 26510589
    41. Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities. PMID: 25084101
    42. The genetic variations of KISS1 gene can be contributing factors of development of CPP. PMID: 25120323
    43. Serum kisspeptin levels were significantly lower in all infertile males as compared to the fertile males. PMID: 25556380
    44. KISS1 expression in the primary site of colorectal cancer could become a useful marker, with its increased levels indicating an advanced disease and a worse prognosis. PMID: 26010933
    45. Kiss-1 may be a putative metastasis suppressor molecule in human colorectal cancer. PMID: 25260785
    46. These data demonstrated that upregulated UHRF1 increases bladder cancer cell invasion by epigenetic silencing of KiSS1. PMID: 25272010
    47. Suggest that KISS1 is down-regulated in cancer tissues via promoter hypermethylation. PMID: 25110434
    48. KiSS-1, might be an important biological marker involved in the carcinogenesis, metastasis, and invasion of gallbladder adenocarcinoma. PMID: 25688501
    49. Kisspeptin effect on endothelial monocyte activating polypeptide II (EMAP-II)-associated lymphocyte cell death and metastases in colorectal cancer patients PMID: 24395571
    50. Decreased expression of KISS1R seems to attenuate signaling of the KISS1/KISS1R system, possibly leading to tumor growth PMID: 25667462

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  • 相关疾病：
    Hypogonadotropic hypogonadism 13 with or without anosmia (HH13)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    KISS1 family
  • 组织特异性：
    Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in ch
  • 数据库链接：

    HGNC: 6341

    OMIM: 603286

    KEGG: hsa:3814

    STRING: 9606.ENSP00000356162

    UniGene: Hs.95008