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  4. Recombinant Human Leukocyte cell-derived chemotaxin-2 (LECT2)

Recombinant Human Leukocyte cell-derived chemotaxin-2 (LECT2)

  • 货号：
    CSB-YP012855HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012855HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012855HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012855HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012855HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LECT2
  • Uniprot No.：
  • 别名：
    chm II; chm2; Chondromodulin II; hLECT2; LECT 2; LECT-2; LECT2; LECT2_HUMAN; Leukocyte cell derived chemotaxin 2; Leukocyte cell-derived chemotaxin-2; MGC126628
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-151
  • 氨基酸序列
    GP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Does not show metalloendopeptidase activity.
  • 基因功能参考文献：
    1. Overexpression of LECT2 or treatment with a recombinant LECT2 protein impaired the colony-forming ability and motility of non-small cell lung cancer cells harboring high levels of activated EGFR and MET. PMID: 30453282
    2. Circulating LECT2 concentrations were increased in individuals with NAFLD and those with MetS, but not in those with atherosclerosis. The relationship between LECT2 and both NAFLD and MetS might be mediated by its association with abdominal obesity and lipid metabolism. PMID: 28376109
    3. VFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia PMID: 28278265
    4. LECT2 was found to be catalytically inactive as a metalloendopeptidase against various types of peptide sequences, including pentaglycine. PMID: 27334921
    5. the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis. PMID: 28039493
    6. findings indicated that serum LECT2 level is negatively associated with the presence of diabetic retinopathy and suggest that low circulating LECT2 level is a risk factor for diabetic retinopathy PMID: 27816666
    7. LECT2 amyloidosis is prevalent among Hispanic decedents in New Mexico. PMID: 26912093
    8. ALECT2, which was initially thought to affect mainly Hispanics in the United States, appears to represent an important and likely underrecognized etiology of chronic kidney disease among Egyptians and probably in other ethnic groups around the world PMID: 26867784
    9. Localized LECT2 amyloidosis of the adrenal gland with coexisting MGUS: a diagnostic challenge. PMID: 26048244
    10. LECT2 immunostain is useful in confirming subtype of amyloid within the liver in ALECT2.. PMID: 25602789
    11. Amyloidosis derived from leukocyte chemotactic factor 2 (ALECT2) is a recently described disease. Here, we report the characteristics and outcome of 72 patients with renal ALECT2, which included 19 who had another kidney disease on biopsy. PMID: 24451324
    12. There were no mutations detected in the LECT2 gene, although all renal leukocyte chemotactic factor 2 amyloidosis patients tested were homozygous for the G nucleotide in a non-synonymous SNP at position 172. PMID: 24522497
    13. LECT2 is regulated by beta-catenin in HCC in both mice and men, but serum LECT2 reflects beta-catenin activity only in mice. Serum LECT2 could be a potential biomarker of HCC in patients. PMID: 24892551
    14. First Nations people from British Columbia who presented with chronic kidney disease, were found to be due to LECT2 amyloidosis. PMID: 25064673
    15. The study indicates that serum LECT2 levels are increased by obesity and fatty liver, and suggests that LECT2 is a novel obesity-related protein. PMID: 24390366
    16. The data from this study show that weak LECT2 staining should be regarded as indeterminate or a negative result and does not per se allow diagnosis of specific amyloid type. The diagnosis of LECT2 renal amyloidosis may require LMD/MS confirmation. PMID: 24792621
    17. These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin resistance. PMID: 24478397
    18. ALect2 is a common cause of hepatic amyloidosis in the population of the United States, and subtyping hepatic amyloid deposits by an accurate analytic method such as MS is required for optimal clinical management of hepatic amyloidosis patients PMID: 24415538
    19. These findings reveal a novel, specific inhibitory function of LECT2 in hepatocellular carcinoma by the direct binding and inactivation of MET. PMID: 24114941
    20. preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2). PMID: 23519812
    21. Re-expression of LECT2 significantly reduced the migration and invasion of human hepatocellular carcinoma cells in vitro and significantly reduced their growth in vivo. PMID: 21394108
    22. LECT2-associated renal amyloidosis represents a unique and perhaps not uncommon disease, especially in Mexican Americans. PMID: 20951486
    23. LECT2, which encodes a protein with chemotactic properties for human neutrophils, is a direct target gene of Wnt/beta-catenin signaling in the liver. PMID: 15239100
    24. LECT2 participates in liver regeneration and injury following hepatectomy. PMID: 15561248
    25. Serum LECT2 levels may be a prognostic indicator of recovery from liver failure. PMID: 15561249

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    LECT2/MIM-1 family
  • 组织特异性：
    Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.
  • 数据库链接：

    HGNC: 6550

    OMIM: 602882

    KEGG: hsa:3950

    STRING: 9606.ENSP00000274507

    UniGene: Hs.512580