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  4. Recombinant Human Leucine-rich repeat transmembrane neuronal protein 3 (LRRTM3), partial

Recombinant Human Leucine-rich repeat transmembrane neuronal protein 3 (LRRTM3), partial

  • 中文名称：
    人LRRTM3重组蛋白
  • 货号：
    CSB-YP801239HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LRRTM3重组蛋白
  • 货号：
    CSB-EP801239HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LRRTM3重组蛋白
  • 货号：
    CSB-EP801239HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LRRTM3重组蛋白
  • 货号：
    CSB-BP801239HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LRRTM3重组蛋白
  • 货号：
    CSB-MP801239HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LRRTM3
  • Uniprot No.：
  • 别名：
    Leucine rich repeat transmembrane neuronal protein 3; Leucine-rich repeat transmembrane neuronal protein 3; LRRT3_HUMAN; Lrrtm3; MGC131810; PRO1693; UNQ803
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation. May play a role in the development and maintenance of the vertebrate nervous system.
  • 基因功能参考文献：
    1. LRRTM3 polymorphisms may play a role in the pathogenesis of late-onset Alzheimer's disease (LOAD) in a Northern Han Chinese population. PMID: 24463050
    2. protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD PMID: 23750206
    3. LRRTM3 is not an essential regulator of amyloid-beta production in adult mice; there are no differences in genotype between levels of Abeta or Abeta protein precursor C-terminal fragments in vivo. PMID: 22710909
    4. One single-nucleotide polymorphism in the promoter region and a block of 4 single-nucleotide polymorphisms in intron 2 were associated with AD in the National Institute on Aging Late-Onset Alzheimer's Disease data set or the Caribbean Hispanic data set. PMID: 22393166
    5. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease. PMID: 21598020
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20678249
    7. Data suggest that LRRTM3 is a functional and positional candidate gene for Alzheimer disease, and, given its receptor-like structure and restricted expression, a potential therapeutic target. PMID: 17098871
    8. An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease. PMID: 19105203
    9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19105203

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    LRRTM family
  • 组织特异性：
    Expressed in neuronal tissues.
  • 数据库链接：

    HGNC: 19410

    OMIM: 610869

    KEGG: hsa:347731

    STRING: 9606.ENSP00000355187

    UniGene: Hs.652155