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  4. Recombinant Human Leucine carboxyl methyltransferase 2 (LCMT2)

Recombinant Human Leucine carboxyl methyltransferase 2 (LCMT2)

  • 中文名称：
    人LCMT2重组蛋白
  • 货号：
    CSB-YP012809HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人LCMT2重组蛋白
  • 货号：
    CSB-EP012809HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人LCMT2重组蛋白
  • 货号：
    CSB-EP012809HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人LCMT2重组蛋白
  • 货号：
    CSB-BP012809HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人LCMT2重组蛋白
  • 货号：
    CSB-MP012809HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LCMT2
  • Uniprot No.：
  • 别名：
    KIAA0547; LCMT 2; Lcmt2; LCMT2_HUMAN; Leucine carboxyl methyltransferase 2; MGC9534; p21WAF1/CIP1 promoter interacting protein; p21WAF1/CIP1 promoter-interacting protein; PPM2; tRNA Wybutosine synthesizing protein 4; tRNA wybutosine synthesizing protein 4 homolog; tRNA wybutosine-synthesizing protein 4 homolog; tRNA yW synthesizing protein 4; tRNA yW synthesizing protein 4 homolog; tRNA yW-synthesizing protein 4 homolog; TYW4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-686
  • 氨基酸序列
    MGPRSRERRA GAVQNTNDSS ALSKRSLAAR GYVQDPFAAL LVPGAARRAP LIHRGYYVRA RAVRHCVRAF LEQIGAPQAA LRAQILSLGA GFDSLYFRLK TAGRLARAAV WEVDFPDVAR RKAERIGETP ELCALTGPFE RGEPASALCF ESADYCILGL DLRQLQRVEE ALGAAGLDAA SPTLLLAEAV LTYLEPESAA ALIAWAAQRF PNALFVVYEQ MRPQDAFGQF MLQHFRQLNS PLHGLERFPD VEAQRRRFLQ AGWTACGAVD MNEFYHCFLP AEERRRVENI EPFDEFEEWH LKCAHYFILA ASRGDTLSHT LVFPSSEAFP RVNPASPSGV FPASVVSSEG QVPNLKRYGH ASVFLSPDVI LSAGGFGEQE GRHCRVSQFH LLSRDCDSEW KGSQIGSCGT GVQWDGRLYH TMTRLSESRV LVLGGRLSPV SPALGVLQLH FFKSEDNNTE DLKVTITKAG RKDDSTLCCW RHSTTEVSCQ NQEYLFVYGG RSVVEPVLSD WHFLHVGTMA WVRIPVEGEV PEARHSHSAC TWQGGALIAG GLGASEEPLN SVLFLRPISC GFLWESVDIQ PPITPRYSHT AHVLNGKLLL VGGIWIHSSS FPGVTVINLT TGLSSEYQID TTYVPWPLML HNHTSILLPE EQQLLLLGGG GNCFSFGTYF NPHTVTLDLS SLSAGQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
  • 基因功能参考文献：
    1. Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A. PMID: 22253232
    2. This paper reports crystal structures of a yeast homolog, TYW4. PMID: 19287006
    3. Cigarette smoke-induced oxidative stress and TGF-beta1 increase its expression in alveolar epithelial cells PMID: 12485877
    4. Inacativaton of this cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders. PMID: 15813917
    5. p21WAF1 and Bax may be used as the markers in the assessment of GIST malignant potential. PMID: 16830365
    6. In conclusion, we report that the transcription factor Sp1 involved in the p38MAPK-mediated control of p21WAF1 regulation on VSMC in response to BITC has now been identified. PMID: 17026958

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  • 蛋白家族：
    Methyltransferase superfamily, LCMT family
  • 数据库链接：

    HGNC: 17558

    OMIM: 611246

    KEGG: hsa:9836

    STRING: 9606.ENSP00000307214

    UniGene: Hs.200596