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  4. Recombinant Human Kelch repeat and BTB domain-containing protein 6 (KBTBD6)

Recombinant Human Kelch repeat and BTB domain-containing protein 6 (KBTBD6)

  • 货号：
    CSB-YP774812HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP774812HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP774812HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP774812HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP774812HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KBTBD6
  • Uniprot No.：
  • 别名：
    KBTB6_HUMAN; KBTBD6; Kelch repeat and BTB (POZ) domain containing 6; Kelch repeat and BTB domain-containing protein 6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-674
  • 氨基酸序列
    MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE SFEVLVDYCY TGRVSLSEAN VERLYAASDM LQLEYVREAC ASFLARRLDL TNCTAILKFA DAFGHRKLRS QAQSYIAQNF KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC HVAVQWLEAA PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG HPRDPFLCCD PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ PRTDLWVYKP AQNSWQQLAD RLLCREGMDV AYLNGYIYIL GGRDPITGVK LKEVECYNVK RNQWALVAPL PHSFLSFDLM VIRDYLYALN SKRMFCYDPS HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV RAEWRQMNNI PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS EPDSESGSSS SLSDDDFWVR VAPQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex.
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    HGNC: 25340

    OMIM: 617738

    KEGG: hsa:89890

    STRING: 9606.ENSP00000368799

    UniGene: Hs.534040