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  4. Recombinant Human Jerky protein homolog (JRK)

Recombinant Human Jerky protein homolog (JRK)

  • 货号：
    CSB-YP525639HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP525639HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP525639HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP525639HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP525639HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    JRK
  • Uniprot No.：
  • 别名：
    JRK; JH8; Jerky protein homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-520
  • 氨基酸序列
    MSTLYDIRAH KAQLLRFFAS SDSNKALEQR RTLHTPKLEH LDRVLYEWFL GKRSEGVPVS GPMLIEKAKD FYEQMQLTEP CVFSGGWLWR FKARHGIKKL DASSEKQSAD HQAAEQFCAF FRSLAAEHGL SAEQVYNADE TGLFWRCLPN PTPEGGAVPG PKQGKDRLTV LMCANATGSH RLKPLAIGKC SGPRAFKGIQ HLPVAYKAQG NAWVDKEIFS DWFHHIFVPS VREHFRTIGL PEDSKAVLLL DSSRAHPQEA ELVSSNVFTI FLPASVASLV QPMEQGIRRD FMRNFINPPV PLQGPHARYN MNDAIFSVAC AWNAVPSHVF RRAWRKLWPS VAFAEGSSSE EELEAECFPV KPHNKSFAHI LELVKEGSSC PGQLRQRQAA SWGVAGREAE GGRPPAATSP AEVVWSSEKT PKADQDGRGD PGEGEEVAWE QAAVAFDAVL RFAERQPCFS AQEVGQLRAL RAVFRSQQQV RRRRGALGAV VKVEALQEGP GGCGATAQSP LPCSSTAGDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May bind DNA.
  • 基因功能参考文献：
    1. JRK expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of beta-catenin target genes and increased cell proliferation PMID: 26455321
    2. in the adult intestine, Ebd acts independently of Ewg in physiological Wnt signaling, but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd homolog, promotes Wnt pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers PMID: 28708826
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Tigger transposable element derived protein family
  • 组织特异性：
    Expressed ubiquitously.
  • 数据库链接：

    HGNC: 6199

    OMIM: 603210

    KEGG: hsa:8629

    UniGene: Hs.535903