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  4. Recombinant Human Interleukin-11 receptor subunit alpha (IL11RA), partial

Recombinant Human Interleukin-11 receptor subunit alpha (IL11RA), partial

  • 货号：
    CSB-YP623927HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP623927HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP623927HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP623927HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP623927HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CRSDA; hCG_2011440; I11RA_HUMAN; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; IL11RA; Interleukin 11 receptor alpha ; Interleukin 11 receptor alpha chain; Interleukin-11 receptor subunit alpha; MGC2146
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
  • 基因功能参考文献：
    1. The results presented here reveal an additional function in classic IL-11 signaling, highlighting the importance of the IL-11R stalk in IL-11 signaling PMID: 29523682
    2. The D2 domain of the IL-11R contains two N-linked glycans, which are dispensable for its biological activity, but differentially control maturation and intracellular trafficking of the receptor. PMID: 29533934
    3. High IL11RA expression is associated with endometrioid tumours. PMID: 28186993
    4. Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas. PMID: 27920471
    5. These results indicate that IL-11Ralpha is a potential target for the development of molecular targeted therapy and noninvasive tumor imaging in human osteosarcoma. PMID: 25524575
    6. IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population. PMID: 21982075
    7. data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases PMID: 22075555
    8. IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma. PMID: 20553623
    9. IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense PMID: 12200462
    10. the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells PMID: 14701802
    11. IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer. PMID: 14744752
    12. interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma PMID: 15512823
    13. High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma PMID: 16291580
    14. High interleukin 11 receptor is associated with breast cancer PMID: 16614887

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  • 相关疾病：
    Craniosynostosis and dental anomalies (CRSDA)
  • 亚细胞定位：
    [Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein.; [Soluble interleukin-11 receptor subunit alpha]: Secreted.; [Isoform HCR2]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 3 subfamily
  • 组织特异性：
    Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malig
  • 数据库链接：

    HGNC: 5967

    OMIM: 600939

    KEGG: hsa:3590

    STRING: 9606.ENSP00000326500

    UniGene: Hs.591088