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  4. Recombinant Human Inactive serine/threonine-protein kinase PLK5 (PLK5)

Recombinant Human Inactive serine/threonine-protein kinase PLK5 (PLK5)

  • 货号：
    CSB-YP675450HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP675450HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP675450HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP675450HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP675450HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLK5
  • Uniprot No.：
  • 别名：
    PLK5; PLK5P; FG060302; Inactive serine/threonine-protein kinase PLK5; Polo-like kinase 5; PLK-5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-336
  • 氨基酸序列
    MYTVLTGTPP FMASPLSEMY QNIREGHYPE PAHLSANARR LIVHLLAPNP AERPSLDHLL QDDFFTQGFT PDRLPAHSCH SPPIFAIPPP LGRIFRKVGQ RLLTQCRPPC PFTPKEASGP GEGGPDPDSM EWDGESSLSA KEVPCLEGPI HLVAQGTLQS DLAGPEGSRR PEVEAALRHL QLCLDVGPPA TQDPLGEQQP ILWAPKWVDY SSKYGFGYQL LDGGRTGRHP HGPATPRREG TLPTPVPPAG PGLCLLRFLA SEHALLLLFS NGMVQVSFSG VPAQLVLSGE GEGLQLTLWE QGSPGTSYSL DVPRSHGCAP TTGQHLHHAL RMLQSI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.
  • 基因功能参考文献：
    1. we report a three-nucleotide deletion near the C-region of Plk5 that is specifically associated with the lymphatic metastasis in patients with clear cell renal cell carcinoma PMID: 26908440
    2. The human polo-like kinase 5 gene is significantly silenced in astrocytoma and glioblastoma multiforme by promoter hypermethylation, suggesting a tumor suppressor function for this gene. PMID: 21245385
  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily
  • 组织特异性：
    Expressed in the brain, neurons and glial cells. Also expressed in highly differentiated cells, such as the serous acini in the parotid gland, distal and proximal tubules of the kidney, tubules of the seminal gland, Kupffer cells and some hepatocytes in t
  • 数据库链接：

    HGNC: 27001

    KEGG: hsa:126520

    STRING: 9606.ENSP00000466248

    UniGene: Hs.195352