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  4. Recombinant Human Homer protein homolog 1 (HOMER1)

Recombinant Human Homer protein homolog 1 (HOMER1)

  • 货号：
    CSB-RP030074h
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    HOME1_HUMAN; Homer ; HOMER 1A; HOMER 1B ; HOMER 1C; Homer homolog 1 (Drosophila); homer homolog 1; Homer protein homolog 1; homer scaffolding protein 1; Homer; Drosophila; homolog of; 1; Homer; neuronal immediate early gene; 1 ; Homer-1; Homer1; HOMER1A; HOMER1B; HOMER1C; SYN47 ; Ves 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    44.3kDa
  • 表达区域：
    1-354aa
  • 氨基酸序列
    MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
  • 基因功能参考文献：
    1. Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents. PMID: 29923011
    2. Study found the common variant rs7713917 in the HOMER1 gene to be significantly associated with suicide attempt in Chinese patient. PMID: 30219717
    3. Homer 1 rs7713917 gene variant associated with brain structure and function, severity of depression, and antidepressant response in patients affected by a major depressive episode in course of bipolar disorder. PMID: 29079138
    4. This study demonstrate that altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression. PMID: 28815330
    5. Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury PMID: 27075036
    6. Resequencing three candidate genes (HOMER1, SLC6A4, and TEF) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese. PMID: 27964944
    7. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma PMID: 26718835
    8. The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. [review] PMID: 26641965
    9. The mRNA levels of Homer1, IL-1beta, and TNF-alpha in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 and Homer3. PMID: 25551602
    10. these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1. PMID: 25712868
    11. Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of intrahepatic cholangiocarcinoma. PMID: 24815486
    12. data suggest that HOMER1 rs4704559 G allele has a protective role for the development of levodopa adverse effects PMID: 24126708
    13. Polymorphisms of DRD1, DLG4 and HOMER1 are associated with opiate abuse. PMID: 23044706
    14. Overexpression of HOMER1A reduces neuropathic pain hypersensitivity. PMID: 23685007
    15. The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells. PMID: 23821062
    16. This review discusses the association of Homer 1 variants with the etiology of many neurological diseases, such as pain, mental retardation syndromes, Alzheimer's disease, schizophrenia, addiction and traumatic brain injury. PMID: 22749857
    17. HOMER1 encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR activity, and is a novel autism-risk gene. PMID: 22558107
    18. This study reported significant associations between different polymorphisms of the HOMER 1 gene and psychopathology of schizophrenic patients at baseline and between HOMER 1 polymorphisms and therapy response after treatment with atypical antipsychotics. PMID: 20598711
    19. Homer dissociation from its targets evoked by the PPKKFR peptide led to Imin calcium channel activation but not to Imax calcium channel activation in A431 cells. PMID: 20926133
    20. HOMER1 plays a role in the etiology of major depression and genetic variation affects depression via the dysregulation of cognitive and motivational processes. PMID: 20673876
    21. Homer1a transgene expression is transiently upregulated during increases in network activity and evokes agonist-independent signaling of group I metabotropic glutamate receptors that scales down expression of synaptic AMPA receptors. PMID: 21172614
    22. HOMER1 was screened for an association with schizophrenia. PMID: 12815733
    23. Polymorphism in the Homer1 gene is a potential risk factor for the development of cocaine dependence in an African American population. PMID: 16314758
    24. Data indicate that Homer1 plays a critical role in determining the apoptotic susceptibility to TRAIL. PMID: 19376111
    25. study implicates the effects of allele A of the rs4704559 marker in susceptibility to psychotic symptoms in Parkinson disease PMID: 19648775

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  • 亚细胞定位：
    Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, dendritic spine.
  • 蛋白家族：
    Homer family
  • 数据库链接：

    HGNC: 17512

    OMIM: 604798

    KEGG: hsa:9456

    STRING: 9606.ENSP00000334382

    UniGene: Hs.591761