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  4. Recombinant Human Hepatocyte nuclear factor 6 (ONECUT1)

Recombinant Human Hepatocyte nuclear factor 6 (ONECUT1)

  • 中文名称：
    人ONECUT1重组蛋白
  • 货号：
    CSB-YP880058HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ONECUT1重组蛋白
  • 货号：
    CSB-EP880058HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ONECUT1重组蛋白
  • 货号：
    CSB-EP880058HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ONECUT1重组蛋白
  • 货号：
    CSB-BP880058HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ONECUT1重组蛋白
  • 货号：
    CSB-MP880058HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    hepatocyte nuclear factor 6 alpha; Hepatocyte nuclear factor 6; HNF 6; HNF-6; HNF6_HUMAN; HNF6A; One cut domain family member 1; One cut homeobox 1; Onecut1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-465
  • 氨基酸序列
    MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
  • 基因功能参考文献：
    1. Reduced HNF6 expression is associated with metastasis of cholangiocarcinoma. PMID: 26825606
    2. HNF6 is a novel host factor that can restrict hepatitis B virus replication via both transcriptional and posttranscriptional mechanisms. PMID: 25653429
    3. The negative correlation between HNF6 expression and pancreatic cancer progression suggests that HNF6 maintains pancreatic epithelial homeostasis, and that its loss contributes to the progression from intraepithelial neoplasms to ductal adenocarcinoma. PMID: 24638272
    4. HNF6 plays an important role in the gene regulation of CYP3A4 during development from the fetal period to the postnatal period. PMID: 23291635
    5. HNF6 inhibits EMT, cell migration, and invasive growth through a mechanism involving the transcriptional activation of p53. PMID: 24022481
    6. Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2. PMID: 23472758
    7. HNF6 and Sox9 are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer. PMID: 22271799
    8. Hepatocyte nuclear factor 6 is one of the liver-enriched transcription factors, it utilizes the bipartite onecut-homeodomain sequence to localize to the nuclear compartment and bind specific DNA sequences of numerous target gene promoters PMID: 21893194
    9. HNF6 has a role as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2 PMID: 12509444
    10. These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells. PMID: 14570708
    11. identifed systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II in human liver and pancreatic islets PMID: 14988562
    12. HNF6 protein stability is controlled by CBP acetylation PMID: 15304484
    13. A comparision of gene expression patterns induced by hepatic nuclear factors, HNF6, HNF4alpha and HNF1beta, in a pancreatic beta-cell line. PMID: 15520459
    14. ONECUT1 expression is lost in pancreatic cancer cells, suggesting a tumor suppressor function in this malignancy. PMID: 18097590
    15. Results suggest that HNF-6 is a novel target of small heterodimer partner in the regulation of gluconeogenesis. PMID: 18459945

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CUT homeobox family
  • 组织特异性：
    Highly expressed in liver; lower expression in testis and skin.
  • 数据库链接：

    HGNC: 8138

    OMIM: 604164

    KEGG: hsa:3175

    STRING: 9606.ENSP00000302630

    UniGene: Hs.555318