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  4. Recombinant Human HMG box-containing protein 1 (HBP1)

Recombinant Human HMG box-containing protein 1 (HBP1)

  • 中文名称：
    人HBP1重组蛋白
  • 货号：
    CSB-YP010158HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HBP1重组蛋白
  • 货号：
    CSB-EP010158HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HBP1重组蛋白
  • 货号：
    CSB-EP010158HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HBP1重组蛋白
  • 货号：
    CSB-BP010158HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HBP1重组蛋白
  • 货号：
    CSB-MP010158HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HBP1
  • Uniprot No.：
  • 别名：
    FLJ16340; HBP 1; HBP1; HBP1_HUMAN; High mobility group box transcription factor 1; HMG box containing protein 1; HMG box transcription factor 1; HMG box-containing protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-514
  • 氨基酸序列
    MVWEVKTNQM PNAVQKLLLV MDKRASGMND SLELLQCNEN LPSSPGYNSC DEHMELDDLP ELQAVQSDPT QSGMYQLSSD VSHQEYPRSS WNQNTSDIPE TTYRENEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA RPPPVSSSSK SEPAFPHHHW KEETPVRHER ANSESESGIF CMSSLSDDDD LGWCNSWPST VWHCFLKGTR LCFHKGSNKE WQDVEDFARA EGCDNEEDLQ MGIHKGYGSD GLKLLSHEES VSFGESVLKL TFDPGTVEDG LLTVECKLDH PFYVKNKGWS SFYPSLTVVQ HGIPCCEVHI GDVCLPPGHP DAINFDDSGV FDTFKSYDFT PMDSSAVYVL SSMARQRRAS LSCGGPGGQD FARSGFSKNC GSPGSSQLSS NSLYAKAVKN HSSGTVSATS PNKCKRPMNA FMLFAKKYRV EYTQMYPGKD NRAISVILGD RWKKMKNEER RMYTLEAKAL AEEQKRLNPD CWKRKRTNSG SQQH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
  • 基因功能参考文献：
    1. Study shows that RORbeta is a transcriptional enhancer of inhibitor HBP1 of the Wnt pathway. NRIP2 prevents RORbeta to bind with downstream HBP1 promoter regions and reduces the transcription of HBP1. These results provide evidence that interactions between NRIP2, RORbeta, and HBP1 mediate a new mechanism for CCIC self-renewal via the Wnt activity. PMID: 28137278
    2. Low HBP1 expression is associated with invasive oral cancer. PMID: 28099936
    3. induced premature senescence and apoptosis. Furthermore, the Pim-1-HBP1 positive feedback loop exerts its effect by regulating the senescence markers DNMT1 and p16 and the apoptosis marker Bax. The Pim-1-HBP1 axis thus constitutes a novel checkpoint pathway critical for the inhibition of tumorigenesis. PMID: 28348080
    4. miR155 may contribute to the progression and growth of Colorectal carcinomaby enhancing the Wnt/betacatenin pathway in an HBP1associated mechanism. PMID: 26780942
    5. Data suggest HMG-box transcription factor (HBP1) as a target in prostate cancer radiotherapy. PMID: 26942107
    6. Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. PMID: 27129219
    7. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
    8. HBP1-mediated Wnt signaling is involved with the role of miR-155 in osteosarcoma progression. PMID: 25666090
    9. Hbp1 plays a crucial role in regulating the timing of cortical neurogenesis by elongating the cell cycle and that it is essential for normal cortical development. PMID: 26041766
    10. HBP1 is a suppressor of cancer progression and a regulator of CTNNB1 gene transcription. PMID: 24895061
    11. miR-96/HBP1/Wnt/beta-catenin regulatory circuitry promotes the proliferation of glioma cell PMID: 24931370
    12. HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response to growth factors. PMID: 24762137
    13. acetylation of TCF4E is a novel regulatory mechanism that diversifies the transcriptional output of Wnt/beta-catenin signaling PMID: 23613959
    14. HBP1 represses the DNMT1 gene through binding a high-affinity site in the DNMT1 promoter. PMID: 23249948
    15. Cis-acting regulatory polymorphisms acting on HBP1 contribute to the osteoarthritis association signal at chromosome 7q22. PMID: 22586168
    16. miR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/beta-catenin PMID: 20505989
    17. HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. PMID: 20581871
    18. HBP1 directly inhibits MIF gene transcription, which is overexpressed in prostatic cancer. PMID: 20383199
    19. HBP1 binds c-Myc in cells, and expression of HBP1 inhibits c-Myc transactivational activity at least partly by preventing c-Myc binding to target gene promoters. PMID: 20008325
    20. NMR study of the AXH domain PMID: 14872137
    21. Results indicate that HBP1 may contribute to the regulation of NADPH oxidase-dependent superoxide production through transcriptional repression of the p47phox gene. PMID: 15024088
    22. HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations PMID: 15235594
    23. in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation PMID: 16179914
    24. Transgenic mice overexpressing HBP1 exhibit altered thymus cellularity and decreased thymocyte development. PMID: 16210625
    25. EGCG blocks Wnt signaling by inducing the HBP1 transcriptional repressor and inhibits aspects of invasive breast cancer PMID: 16495219
    26. these studies highlight p38 MAPK, HBP1, and RB as important components for a premature-senescence pathway with possible clinical relevance to breast cancer. PMID: 16966377
    27. HBP1 transcriptional repressor alterations are associated with invasive breast cancer PMID: 17616670
    28. HBP1 regulates the cell cycle in liver regeneration and provides evidence for a role in tissue maintenance. PMID: 11486012
    29. HBP1 is a suppressor of Wnt signalling and lies in a region that is mutated in cancer. PMID: 11500377
    30. HBP1 was isolated as a cell cycle inhibitor and HMG-box transcriptional repressor. PMID: 9030690

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 23200

    KEGG: hsa:26959

    STRING: 9606.ENSP00000222574

    UniGene: Hs.162032