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  4. Recombinant Human GTP-binding protein Rit2 (RIT2)

Recombinant Human GTP-binding protein Rit2 (RIT2)

  • 中文名称：
    人RIT2重组蛋白
  • 货号：
    CSB-YP860769HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RIT2重组蛋白
  • 货号：
    CSB-EP860769HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RIT2重组蛋白
  • 货号：
    CSB-EP860769HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RIT2重组蛋白
  • 货号：
    CSB-BP860769HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RIT2重组蛋白
  • 货号：
    CSB-MP860769HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RIT2
  • Uniprot No.：
  • 别名：
    GTP binding protein Rit2; GTP binding protein Roc2; GTP-binding protein Rit2; Ras like protein expressed in neurons; Ras like without CAAX 2; Ras like without CAAX protein 2; Ras-like protein expressed in neurons; Ras-like without CAAX protein 2; RIBA; Ric (Drosophila) like; Ric like; Ric like, expressed in neurons; RIN; RIT2; RIT2_HUMAN; ROC2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-217
  • 氨基酸序列
    MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
  • 基因功能参考文献：
    1. RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. PMID: 29860660
    2. Significant association of RIT2 Polymorphisms was observed between rs12456492 and two disorders, Parkinson's disease and essential tremor PMID: 26941103
    3. An RIT2 gene variant was found to be a risk factor for autism spectrum disorder in Iranian patients. PMID: 28190241
    4. Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter. PMID: 28214997
    5. RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese. PMID: 27889863
    6. The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association. PMID: 26334395
    7. findings increase the likelihood of association between Parkinson's disease and RIT2 variant in Asian populations PMID: 25146456
    8. performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals PMID: 25559334
    9. Its polymorphism is associated with Parkinson's disease in a Han Chinese population. PMID: 25457028
    10. The data of this study suggested that the RIT2 polymorphisms are associated with Parkinson disease etiology. PMID: 25534083
    11. the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis] PMID: 26188085
    12. failed to replicate the RIT2 rs12456492 variant as a genetic risk factor for Parkinson's disease in our population. PMID: 23635658
    13. These studies confirm the expression of RIT2 in retinal neuronal cells. PMID: 23805044
    14. This meta-analysis identifies a novel Parkinson's disease locus, RIT2, that replicates several previously identified loci on chromosome 18. PMID: 22451204
    15. Rin interacts directly with dopamine transporter DAT in a protein kinase (PK)C-regulated manner and is required for PKC-mediated DAT internalization. PMID: 21957239
    16. Modulates the activation of the Brn-3a regulated egr-1 promoter by the N-terminal domain of Brn-3a PMID: 12934100
    17. Neuron-specific small GTPase Rin is involved in downstream signaling of plexin B3. PMID: 16122393
    18. observations establish Rin as a neuronal specific regulator of neurotrophin signaling, required to couple NGF stimulation to sustain activation of p38 MAP kinase and b-Raf signaling cascades required for neuronal development PMID: 16157584

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  • 亚细胞定位：
    Nucleus. Cell membrane.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Neuron-specific.
  • 数据库链接：

    HGNC: 10017

    OMIM: 609592

    KEGG: hsa:6014

    STRING: 9606.ENSP00000321805

    UniGene: Hs.464985