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  4. Recombinant Human Exocyst complex component 7 (EXOC7)

Recombinant Human Exocyst complex component 7 (EXOC7)

  • 货号：
    CSB-YP007886HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007886HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007886HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007886HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007886HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    2 5 3p; DKFZp686J04253; EX070; EXO70; Exo70p; EXOC 1; EXOC 7; EXOC1; Exoc7; EXOC7_HUMAN; Exocyst complex component 7; Exocyst complex component Exo70; FLJ40965; FLJ46415; KIAA1067; Rexo70; YJL085W
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-735
  • 氨基酸序列
    MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL AGRDDMLDVE TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ DALDGLMLEG ENIVSAARKA IVRHDFSTVL TVFPILRHLK QTKPEFDQVL QGTAASTKNK LPGLITSMET IGAKALEDFA DNIKNDPDKE YNMPKDGTVH ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF SKRLLSTYIC KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ IIKERFKGFN DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL QKFGSVPFTK NPEKYIKYGV EQVGDMIDRL FDTSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion. It is required for neuron survival and plays an essential role in cortical development.
  • 基因功能参考文献：
    1. the results identify Exo70 as a novel transcriptional target of HNF4alpha to promote cell cycle progression in hepatoma, thus provide a basis for the development of therapeutic strategies for hepatocellular carcinoma. PMID: 26848864
    2. the expression of CTTN, Exo70 and MMP-9 in HCC cells was detected and their relations with the ability of migration and invasion of hepatoma carcinoma cells were evaluated PMID: 27025610
    3. GIV directly and constitutively binds the exocyst complex subunit Exo-70 and also associates with GLUT4-storage vesicles (GSVs) exclusively upon insulin stimulation. PMID: 26514725
    4. We show that Exo70, a component of the exocyst complex, undergoes isoform switching mediated by ESRP1, a pre-mRNA splicing factor that regulates epithelial mesenchymal transition. PMID: 24331928
    5. Exo70 thus represents a membrane-bending protein that may couple actin dynamics and plasma membrane remodeling for morphogenesis. PMID: 23948253
    6. Exo70 is involved in caveolin-1 recycling to the plasma membrane during re-adhesion of the cells to the substratum. PMID: 23300727
    7. Exocyst component Exo70 is a direct substrate of the extracellular signal-regulated kinases 1/2, their phosphorylation enhances the binding of Exo70 to other exocyst components and promotes the assembly of the exocyst complex. PMID: 22595671
    8. PIPKIgamma and phosphatidyl inositol phosphate pools at nascent E-cadherin contacts cue Exo70 targeting and orient the tethering of exocyst-associated E-cadherin PMID: 22049025

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Midbody, Midbody ring.
  • 蛋白家族：
    EXO70 family
  • 组织特异性：
    Abundant in the ventricular zone, the outer subventricular zone and the cortical plate of the fetal cortex.
  • 数据库链接：

    HGNC: 23214

    OMIM: 608163

    KEGG: hsa:23265

    STRING: 9606.ENSP00000334100

    UniGene: Hs.514496