Recombinant Human Endothelial transcription factor GATA-2 (GATA2)

1. Two GATA2 mutants (gT354M and gC373R) bound the key hematopoietic differentiation factor PU.1. PMID: 28642594
2. Study identifies the GATA2 transcription factor as a critical regulator of matrix stiffness induced transcriptional program in the in lymphatic endothelial cells (LECs). As opposed to the previously reported activation of GATA2 by increased mechanical stimulus upon exposure of LECs to stiff matrix or oscillatory flow, study found that GATA2 expression is increased in LECs grown on a soft matrix. PMID: 29666442
3. endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction. PMID: 28569748
4. To analyze the outcomes of COS in women with GATA2 deficiency. PMID: 29532200
5. Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 and GATA3 appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein; GATA2 = endothelial transcription factor GATA-2; GATA3 = T-cell-specific transcription factor GATA-3) PMID: 29275211
6. Gata2 and miR-124-3p are potential novel reporter biomolecules for ovarian cancer. PMID: 28937943
7. although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2, 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy PMID: 28381408
8. in our study on a large cohort of CEBPAmut AML patients, we found a high coincidence of GATA2mut, in particular within the subgroup of patients with CEBPAbi mutations PMID: 27375010
9. Androgen receptor transcriptionally regulates semaphorin 3C in a GATA2-dependent manner in prostate tumor cells. PMID: 28038451
10. Study identified the novel role of transcription factors GATA-2 and GATA-3 in suppressing MICA/B expression in HBV-infected human hepatoma cells. PMID: 27528231
11. GATA2 mutation-related immunodeficiency may predispose to Epstein-Barr virus-associated subacute demyelinating polyradiculoneuropathy by both viral susceptibility and immune dysregulation PMID: 28093780
12. The absence of deleterious mutations in this large cohort of familial aggregations of hematological malignancies may strengthen the hypothesis that GATA2 mutations are an important predisposing factor, although as a secondary genetic event, required for the development of overt malignant disease PMID: 28752392
13. Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage. PMID: 27783953
14. p38-dependent mechanism that phosphorylates GATA-2 and increases GATA-2 target gene activation has been demonstrated. This mechanism establishes a growth-promoting chemokine/cytokine circuit in acute myeloid leukemia cells. PMID: 27545880
15. we report a family with a null mutation in GATA2 and Emberger syndrome with variable expressivity and incomplete penetrance. This case emphasizes the need of genetic interactions to produce specific phenotypes in the clinical spectrum of GATA2 deficiency, where no precise genotype-phenotype correlation has been found. PMID: 28271814
16. Studied GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers. Seven patients with GATA2 deficiency developed severe EBV disease. Also found GATA2 to be the first gene associated with EBV hydroa vacciniforme-like lymphoma. PMID: 27169477
17. GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4. PMID: 26710799
18. decline of GATA2 resulting from mutations contributes to the erythroid commitment, differentiation and the development of AEL PMID: 27389056
19. the distinct mechanisms by which GATA2 and FOXA1 regulate AR cistrome and suggest that FOXA1 acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer. PMID: 26751772
20. adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire. PMID: 28209719
21. reducing GATA2 expression or inhibition of its transcription activity can relieve the drug resistance of acute myeloid leukemia cells and it would be helpful for eliminating the leukemia cells in patients PMID: 28114350
22. we suggest screening for GATA2 mutations in pediatric myelodysplastic syndrome, preferentially in patients with impaired B-cell homeostasis in bone marrow and peripheral blood (low number of progenitors, intronRSS-Kde recombination excision circles and naive cells. PMID: 27013649
23. Knockdown of GATA-2 caused NGB expression to drop dramatically, indicating GATA-2 as an essential transcription factor for the activation of NGB expression via binding to a novel distal regulatory element of NGB. PMID: 27651453
24. analysis of two separate cases of pediatric AML/MDS with underlying GATA2 mutations who underwent a successful umbilical cord hematopoietic stem cell transplantation using two different conditioning regimens [case report/review] PMID: 27416790
25. germ line mutations in GATA2 are associated with GATA2 deficiency syndrome, whereas acquired mutations are seen in myelodysplastic syndrome, acute myeloid leukemia, and in blast crisis transformation of chronic myeloid leukemia. PMID: 28179280
26. the results of this study demonstrated that high expression of GATA2 is correlated with worse survival outcomes in KRAS mutant colorectal cancer patients PMID: 27460045
27. Letter/Case Report: frameshift mutation in GATA2 resulting in Emberger syndrome in Korean patient. PMID: 26767875
28. GATA2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
29. we screened 995 transcription factor genes and revealed that CITED2 acts as a GATA-2 activator in human hematopoietic cells. These results provide novel insights into and further identify the regulatory mechanism of GATA-2 PMID: 26325290
30. results demonstrated that GATA2 single nucleotide polymorphism rs2335052 is an independent predictor for prognosis of colorectal cancer patients. PMID: 26287967
31. Data show that the Lim domain only 2 (LMO2) regulatory element (element-25) region consists of transcription factor GATA2-binding myeloid ennhancer and RUNX protein-binding T-cell repressor. PMID: 26161748
32. High GATA2 promotes glioma progression through EGFR/ERK/Elk-1 pathway. PMID: 25707769
33. In children and adults with severe GM-CSF negative PAP a close cooperation between pneumologists and hemato-oncologists is needed to diagnose the underlying diseases, some of which are caused by mutations of transcription factor GATA2. PMID: 26264606
34. The results of this study showed that GATA2 regulates the development of cochlear hair cells and the inferior colliculus (IC), which are important in tonotopic mapping. PMID: 24614497
35. GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia is associated with concurrent thrombocytopenia. PMID: 25676417
36. data unveil essential roles for GATA2 in the lymphatic vasculature and explain why a select catalogue of human GATA2 mutations results in lymphedema. PMID: 26214525
37. Altered binding of GATA2 (and Sp1/TBP) mediates aberrant MAOA expression under pathophysiological conditions. PMID: 25810277
38. Transgenic human GATA2 appeared to induce growth via downstream activation of Nmyc and Hoxa9 in mice. GATA2 overexpression at low level confers self-renewal capacity to myeloid progenitors and is relevant to myeloid leukemia development. PMID: 25907033
39. the molecular biology, clinical, hematological and immunological features of patients with GATA2 mutations (Review) PMID: 25707267
40. GATA2 plays an important role in regulating the differentiation potential of BM-MSC and contributes to hematopoietic supporting capacity. PMID: 25150255
41. Homozygous CEPBA mutations have a similar gene expression signature as CEPBA double mutations and thus may be considered as equivalent in the presence of GATA2 mutations. PMID: 25611491
42. Ubiquitin-dependent degradation of GATA 2 is promoted by Fbw7, is cyclin B-CDK1-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation. PMID: 25670854
43. The study showed that human GATA2 binds to its own promoter, activating its transcription, and that the p.Arg396Gln mutation impairs the transcription of GATA2. PMID: 25624456
44. one of the targets of p38 in this context is another GATA transcription factor, GATA3, recently demonstrated to promote HSC cycling and restrict their long-term reconstitutive potential downstream of p38 in stress-induced hematopoiesis [9]. PMID: 25092790
45. p38 also induced multisite phosphorylation of wild-type GATA-2, which required a single phosphorylated residue (S192). Phosphorylation of GATA-2, but not T354M, stimulated target gene expression. PMID: 25056917
46. These studies reveal a GATA2-IGF2 aggressiveness axis in lethal prostate cancer and identify a therapeutic opportunity in this challenging disease. PMID: 25670080
47. Data suggest that the original GATA binding protein 2 (GATA2) mutations might be lost during disease progression in GATA2-mutated patients, while novel GATA2 mutations might be acquired at relapse in GATA2-wild patients. PMID: 25241285
48. propose pharmacological inhibition of GATA2 as a first-in-field approach to target AR expression and function and improve outcomes in CRPC PMID: 25489091
49. GATA2 deficiency analysis is important for the differential diagnosis of idiopathic aplastic anemia PMID: 25359990
50. GATA2 is epigenetically repressed in human and mouse lung tumors and its further inhibition is not a valid therapeutic strategy for KRAS mutant lung cancer. PMID: 24807155

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HGNC: 4171

OMIM: 137295

KEGG: hsa:2624

STRING: 9606.ENSP00000345681

UniGene: Hs.367725