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  4. Recombinant Human Dual specificity protein phosphatase CDC14A (CDC14A)

Recombinant Human Dual specificity protein phosphatase CDC14A (CDC14A)

  • 中文名称：
    Recombinant Human Dual specificity protein phosphatase CDC14A(CDC14A),Yeast
  • 货号：
    CSB-YP892158HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Dual specificity protein phosphatase CDC14A(CDC14A),Yeast
  • 货号：
    CSB-EP892158HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Dual specificity protein phosphatase CDC14A(CDC14A),Yeast
  • 货号：
    CSB-EP892158HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Dual specificity protein phosphatase CDC14A(CDC14A),Yeast
  • 货号：
    CSB-BP892158HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Dual specificity protein phosphatase CDC14A(CDC14A),Yeast
  • 货号：
    CSB-MP892158HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CDC14A; Dual specificity protein phosphatase CDC14A; EC 3.1.3.16; EC 3.1.3.48; CDC14 cell division cycle 14 homolog A
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-594
  • 氨基酸序列
    MAAESGELIG ACEFMKDRLY FATLRNRPKS TVNTHYFSID EELVYENFYA DFGPLNLAMV YRYCCKLNKK LKSYSLSRKK IVHYTCFDQR KRANAAFLIG AYAVIYLKKT PEEAYRALLS GSNPPYLPFR DASFGNCTYN LTILDCLQGI RKGLQHGFFD FETFDVDEYE HYERVENGDF NWIVPGKFLA FSGPHPKSKI ENGYPLHAPE AYFPYFKKHN VTAVVRLNKK IYEAKRFTDA GFEHYDLFFI DGSTPSDNIV RRFLNICENT EGAIAVHCKA GLGRTGTLIA CYVMKHYRFT HAEIIAWIRI CRPGSIIGPQ QHFLEEKQAS LWVQGDIFRS KLKNRPSSEG SINKILSGLD DMSIGGNLSK TQNMERFGED NLEDDDVEMK NGITQGDKLR ALKSQRQPRT SPSCAFRSDD TKGHPRAVSQ PFRLSSSLQG SAVTLKTSKM ALSPSATAKR INRTSLSSGA TVRSFSINSR LASSLGNLNA ATDDPENKKT SSSSKAGFTA SPFTNLLNGS SQPTTRNYPE LNNNQYNRSS NSNGGNLNSP PGPHSAKTEE HTTILRPSYT GLSSSSARFL SRSIPSLQSE YVHY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
  • 基因功能参考文献：
    1. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. s therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
    2. Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. PMID: 27259055
    3. Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. PMID: 27323075
    4. hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer PMID: 26747605
    5. These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. PMID: 25503649
    6. hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. PMID: 25463242
    7. Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. PMID: 21233601
    8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
    9. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
    10. human Cdc14A phosphatase disrupts centrosome separation PMID: 11901424
    11. Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. PMID: 12134069
    12. analysis of iron-responsive elements in the 3'UTR of CDC14a protein PMID: 16760464
    13. hCdc14A is differentially expressed in human cancer cells and can interact with both p53 and the Cdk1/cyclin B complex; it may play a role in carcinogenesis PMID: 16784539
    14. Cdc14A may be involved in the cell cycle regulation of Cdc25A stability. PMID: 17172867
    15. RN-tre phosphorylation is critical for efficient hCdc14A association PMID: 17371873
    16. PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. PMID: 17623655
    17. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225

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  • 相关疾病：
    Deafness, autosomal recessive, 105 (DFNB105)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 数据库链接：

    HGNC: 1718

    OMIM: 603504

    KEGG: hsa:8556

    STRING: 9606.ENSP00000354916

    UniGene: Hs.127411