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CDC14A Antibody

  • 货号：
    CSB-PA070087
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UNH5
  • 基因名：
  • 别名：
    CDC14A antibody; Dual specificity protein phosphatase CDC14A antibody; EC 3.1.3.16 antibody; EC 3.1.3.48 antibody; CDC14 cell division cycle 14 homolog A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cdc14a phosphatase.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
  • 基因功能参考文献：
    1. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. s therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. PMID: 28465438
    2. Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. PMID: 27259055
    3. Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. PMID: 27323075
    4. hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer PMID: 26747605
    5. These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. PMID: 25503649
    6. hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. PMID: 25463242
    7. Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. PMID: 21233601
    8. Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. PMID: 20956543
    9. human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. PMID: 20479464
    10. human Cdc14A phosphatase disrupts centrosome separation PMID: 11901424
    11. Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. PMID: 12134069
    12. analysis of iron-responsive elements in the 3'UTR of CDC14a protein PMID: 16760464
    13. hCdc14A is differentially expressed in human cancer cells and can interact with both p53 and the Cdk1/cyclin B complex; it may play a role in carcinogenesis PMID: 16784539
    14. Cdc14A may be involved in the cell cycle regulation of Cdc25A stability. PMID: 17172867
    15. RN-tre phosphorylation is critical for efficient hCdc14A association PMID: 17371873
    16. PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. PMID: 17623655
    17. Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. PMID: 18235225

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  • 相关疾病：
    Deafness, autosomal recessive, 105 (DFNB105)
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Cell projection, kinocilium. Cell projection, stereocilium.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class CDC14 subfamily
  • 数据库链接：

    HGNC: 1718

    OMIM: 603504

    KEGG: hsa:8556

    STRING: 9606.ENSP00000354916

    UniGene: Hs.127411