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  4. Recombinant Human Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6)

Recombinant Human Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6)

  • 货号：
    CSB-YP874831HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP874831HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP874831HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP874831HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP874831HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C1QTNF6
  • Uniprot No.：
  • 别名：
    C1q and tumor necrosis factor related protein 6; C1QT6_HUMAN; C1qtnf6; Complement C1q tumor necrosis factor related protein 6; Complement C1q tumor necrosis factor-related protein 6; CTRP 6; CTRP6; OTTHUMP00000197772; OTTHUMP00000197774; PRO1151; UNQ581; ZACRP6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-259
  • 氨基酸序列
    TFD RAVASGCQRC CDSEDPLDPA HVSSASSSGR PHALPEIRPY INITILKGDK GDPGPMGLPG YMGREGPQGE PGPQGSKGDK GEMGSPGAPC QKRFFAFSVG RKTALHSGED FQTLLFERVF VNLDGCFDMA TGQFAAPLRG IYFFSLNVHS WNYKETYVHI MHNQKEAVIL YAQPSERSIM QSQSVMLDLA YGDRVWVRLF KRQRENAIYS NDFDTYITFS GHLIKAEDD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. The results establish CTRP6 as a novel metabolic/immune regulator linking obesity to adipose tissue inflammation and insulin resistance. PMID: 28726640
    2. We found both the rs229527 allele within C1QTNF6 (odds ratio [OR] = 1.23, confidence interval [95% CI]: 1.12-1.33, pAllelic = 4.60 . 10-6) and the rs2284038 allele within RAC2 (OR = 1.10, 95% CI: 1.01-0.19, pAllelic = 3.00 . 10-2) showed significant associations with Graves' Disease susceptibility. PMID: 28665696
    3. CTRP6 expression was decreased in scar tissues and TGF-beta1-treated dermal fibroblasts. CTRP6 inhibits TGF-beta1-induced the proliferation of dermal fibroblasts. PMID: 27155158
    4. CTRP6 inhibits the proliferation and migration of ovarian cancer cells via blocking IL-8/VEGF pathway. PMID: 26648301
    5. CTRP6 is expressed in human synoviocytes, and CTRP6 levels are increased in RA patients. PMID: 26404464
    6. C1qTNF6 is overexpressed and possibly contributes to tumor angiogenesis by activating the Akt pathway in many hepatocellular carcinomas. PMID: 21508531

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 14343

    OMIM: 614910

    KEGG: hsa:114904

    STRING: 9606.ENSP00000338812

    UniGene: Hs.22011