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  4. Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16)

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 16 (CEACAM16)

  • 货号：
    CSB-YP005158HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005158HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005158HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005158HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005158HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CEACAM16
  • Uniprot No.：
  • 别名：
    CEACAM16; CEAL2Carcinoembryonic antigen-related cell adhesion molecule 16; Carcinoembryonic antigen-like 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Extracellular domain
  • 表达区域：
    21-425
  • 氨基酸序列
    EISITLEPAQ PSEGDNVTLV VHGLSGELLA YSWYAGPTLS VSYLVASYIV STGDETPGPA HTGREAVRPD GSLDIQGILP RHSGTYILQT FNRQLQTEVG YGHVQVHEIL AQPTVLANST ALVERRDTLR LMCSSPSPTA EVRWFFNGGA LPVALRLGLS PDGRVLARHG IRREEAGAYQ CEVWNPVSVS RSEPINLTVY FGPERVAILQ DSTTRTGCTI KVDFNTSLTL WCVSRSCPEP EYVWTFNGQA LKNGQDHLNI SSMTAAQEGT YTCIAKNTKT LLSGSASVVV KLSAAAVATM IVPVPTKPTE GQDVTLTVQG YPKDLLVYAW YRGPASEPNR LLSQLPSGTW IAGPAHTGRE VGFPNCSLLV QKLNLTDTGR YTLKTVTVQG KTETLEVELQ VAPLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
  • 基因功能参考文献：
    1. Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1/CDK4. PMID: 26497080
    2. Data indicate that a heterozygous missense mutation, c.505G>A (p.G169R) in exon 3 of the CEACAM16 gene (carcinoembryonic antigen-related cell adhesion molecule 16) was identified in autosomal dominant nonsyndromic hearing loss family. PMID: 25589040
    3. CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane PMID: 22544735
    4. data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus PMID: 21368133
  • 相关疾病：
    Deafness, autosomal dominant, 4B (DFNA4B)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, CEA family
  • 数据库链接：

    HGNC: 31948

    OMIM: 614591

    KEGG: hsa:388551

    STRING: 9606.ENSP00000385576

    UniGene: Hs.456381