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  4. Recombinant Bovine Caveolin-1 (CAV1)

Recombinant Bovine Caveolin-1 (CAV1)

  • 货号：
    CSB-YP004571BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004571BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004571BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004571BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004571BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CAV1Caveolin-1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-178
  • 氨基酸序列
    SGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMNEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RINTQKEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.
  • 基因功能参考文献：
    1. Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling PMID: 26409042
    2. Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs). PMID: 25419974
    3. these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS. PMID: 24648521
    4. Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism. PMID: 21724868
    5. Data indicate that caveolin-1 expression is required for insulin uptake by aortic endothelial cells. PMID: 20959538
    6. caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts PMID: 15292187
    7. integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation. PMID: 15471980
    8. importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS inhibition by AP-Cav and Cav-1 PMID: 15637154
    9. When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated. PMID: 16325778
    10. alphaCAV1 likely contributes to control the increase in membrane signaling that occurs at the time of ovulation and luteinization. PMID: 16894547
    11. caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration PMID: 17868074
    12. caveolin-1 Tyr(14) is necessary for binding to intermediate filaments, which in turn is required for anterior polarization of caveolin-1 in transmigrating cells PMID: 17955336
    13. Phosphorylation of CAV1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase is reported. PMID: 18188962
    14. XIAP plays a novel role in endothelial cells, interacting with caveolin-1 and acting as a regulator of vascular antiatherogenic function. PMID: 18309102
    15. These data show that insulin acutely regulates eNOS and CAV-1 trafficking to plasma membrane of vascular endothelial cells where their interaction can regulate eNOS activity. PMID: 19608646
    16. TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype PMID: 19710365

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  • 亚细胞定位：
    Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft.
  • 蛋白家族：
    Caveolin family
  • 数据库链接：

    KEGG: bta:281040

    STRING: 9913.ENSBTAP00000023751

    UniGene: Bt.106571